Idiopathic Pulmonary Fibrosis Clinical Trial
Official title:
Pilot Study Phase III to Evaluate the Efficacy and Safety of Trimethoprim-sulfamethoxazole in the Treatment of Idiopathic Pulmonary Fibrosis
First study to test the validity of the treatment of idiopathic pulmonary fibrosis, which
causes inflammation and fibrosis (scarring) of the lung tissue, with cotrimoxazole.
Cotrimoxazole may improve the clinical course of the disease through eradication of
Pneumocystis jiroveci colonization and other mechanisms as inhibiting the activation of
alveolar macrophages and producing alterations in the surfactant system which favours the
persistent activation of the inflammatory response and the development of pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that is clinically manifested
by the appearance of effort dyspnea and impaired lung function.
The natural history of the disease is poorly understood and there is no clear consensus as to
the most appropriate markers for predicting patient outcome.
This pilot controlled trial aims to test the efficacy and safety of cotrimoxazole in the
treatment of IPF. This novel therapeutic strategy, with very encouraging preliminary data is
based on its pathophysiological basis, primarily related to the elimination of Pneumocystis
colonization. That elimination, could serve as a potent weapon for reducing morbidity and
mortality and the cost associated with this devastating disease.
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