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Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension

Idiopathic Intracranial Hypertension Clinical Trial

Official title:
D-dimer and the Use of Anticoagulation in IIH

Clinical Trial Summary

Idiopathic intracranial hypertension (IIH) is a syndrome characterized by elevated intracranial pressure (ICP) of unknown etiology.

The investigators aim to study the quantitative D-dimer level and the role of anticoagulant therapy in the absence of occlusive sinus thrombosis in IIH patients.

Clinical Trial Description

24 patients with IIH according to the modified Dandy criteria were enrolled. Headache impact test (HIT6), ophthalmological assessment including Frisen classification for papilledema, visual acuity, visual field by perimetry, and visual evoked potentials were performed to the patients.

Serum quantitative D-dimer level was measured using the enzyme-linked immunosorbent assay (ELISA) technique for the patients and for 24 healthy matched controls.

Patients were divided into two groups: group (A) received acetazolamide and low molecular weight heparin (LMWH) in a prophylactic dose for 2 weeks while group (B) received acetazolamide only. Both groups continued the acetazolamide 1-2g/day for 6 months.

The investigators followed-up the patients after one and six months later through the HIT6 test and the ophthalmological assessment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03963336
Study type Interventional
Source Fayoum University
Contact
Status Completed
Phase Early Phase 1
Start date July 22, 2017
Completion date August 2, 2018
View Details
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