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Evaluating Raised Intracranial Pressure Using MR Elastography

Idiopathic Intracranial Hypertension Clinical Trial

Official title:
Evaluating Raised Intracranial Pressure Using MR Elastography

Clinical Trial Summary

Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).

Clinical Trial Description

The goal of this study is to evaluate the brain elasticity in patients with idiopathic intracranial hypertension (IIH) and other forms of raised intracranial pressure, such as obstructive hydrocephalus. Investigators will evaluate for a correlation between brain stiffness and opening pressure on lumbar puncture. Investigators will also evaluate for changes in brain stiffness after interventions that are aimed at lowering intracranial pressure, including lumbar punctures, medications, and surgical interventions, such as ventriculoperitoneal shunts. Lastly, investigators will compare MR elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on MRI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03096743
Study type Interventional
Source Mayo Clinic
Contact John J. Chen, M.D., Ph.D.
Phone 507-284-7140
Email chen.john@mayo.edu
Status Recruiting
Phase N/A
Start date January 10, 2017
Completion date December 2025
View Details
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