Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02758470
Other study ID # H16-00896
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date November 2016
Est. completion date June 30, 2017

Study information

Verified date September 2018
Source University of British Columbia
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.


Recruitment information / eligibility

Status Completed
Enrollment 13
Est. completion date June 30, 2017
Est. primary completion date June 30, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

- Age: 18-40 years.

- Regularly physically active

- Male

Exclusion Criteria:

- current or ex-smokers

- pulmonary function <80% of predicted

- esophageal tumour or ulcer

- have had recent (<6 months) musculoskeletal injury or any surgery to the lower leg

- have contraindications to carbonic anhydrase inhibitors (eg. severe or absolute glaucoma, adrenocortical insufficiency, hepatic insufficiency, renal insufficiency, sulfa allergy or an electrolyte imbalance such as hyperchloremic acidosis)

- are obese (BMI >30 Kg/m2)

- taking diuretics, blood thinners, or anti-platelet drugs.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Acetazolamide
250 mg, taken orally three times per day
Methazolamide
100mg, taken orally two times per day. A placebo pill will be taken between each dose of methazolamide to match the timing of doses and the number of pills between study arms.
Other:
Placebo
A placebo will be taken three times per day

Locations

Country Name City State
Canada University of British Columbia Kelowna British Columbia

Sponsors (1)

Lead Sponsor Collaborator
University of British Columbia

Country where clinical trial is conducted

Canada, 

References & Publications (1)

Dominelli PB, McNeil CJ, Vermeulen TD, Stuckless TJR, Brown CV, Dominelli GS, Swenson ER, Teppema LJ, Foster GE. Effect of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue: a randomized controlled trial. J Appl Physiol (1985). 2018 Sep — View Citation

Outcome

Type Measure Description Time frame Safety issue
Other Esophageal and Gastric Pressure Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol
Other Heart Rate Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol
Other Beat-by-beat blood pressure Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol
Primary Change in trans-diaphragmatic pressure generation to supramaximal phrenic nerve stimulation following inspiratory threshold loading. Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study
Primary Change in plantar flexor muscle group torque generation to supramaximal tibial nerve stimulation following an isometric loading protocol Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study
Secondary Maximal inspiratory pressure maneuvers Baseline and immediately following loading protocol
Secondary Maximal Voluntary Contraction of the Plantar Flexor Muscle Group Baseline and immediately following the loading protocol
Secondary Contraction time and half-relaxation time Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol
See also
  Status Clinical Trial Phase
Recruiting NCT04498598 - Structural Modification In Supraglottic Airway Device N/A
Completed NCT05532670 - N600X Low Saturation Accuracy Validation
Enrolling by invitation NCT04106401 - Intravascular Volumes in Hypoxia During Antarctic Confinement N/A
Recruiting NCT05883137 - High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Not yet recruiting NCT05817448 - Hypoxia-induced Autophagy in the Pathogenesis of MAP
Recruiting NCT02661152 - DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC. Phase 3
Terminated NCT02801162 - Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the Reference Standard N/A
Completed NCT02943863 - Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia N/A
Not yet recruiting NCT02201875 - Intrinsic Periodic Pattern of Breathing N/A
Completed NCT01922401 - Inverse Ratio Ventilation on Bariatric Operation N/A
Completed NCT02105298 - Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study) N/A
Active, not recruiting NCT01681238 - Goal-directed Therapy in High-risk Surgery N/A
Completed NCT01463527 - Using Capnography to Reduce Hypoxia During Pediatric Sedation N/A
Completed NCT01507623 - Value of Capnography During Nurse Administered Propofol Sedation (NAPS) N/A
Withdrawn NCT00638040 - The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression N/A
Active, not recruiting NCT06097754 - Intermittent Exogenous Ketosis (IEK) at High Altitude N/A
Completed NCT04589923 - The VISION-Acute Study
Completed NCT05044585 - Evaluation of RDS MultiSense® in Desaturation Analysis in Healthy Volunteers N/A
Completed NCT03659513 - The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
Completed NCT03221387 - Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients N/A