Hypoxia Clinical Trial
Official title:
Comparison of Regional Ventilation Pattern During High Flow Nasal Cannula Between Conventional Low Flow System Nasal Cannula in Patients With Mild to Moderate Hypoxia
High-flow nasal cannula (HFNC) that uses heated and humidified oxygen was recently
introduced for bedside care. It has been shown to be associated with reduced risks of
tracheal intubation rates and mortality in adult hypoxic patients.
The mechanisms of the effects of HFNC are thought to be related to the favorable effects of
the heated and humidified gas, the high-flow rate used to minimize the entrainment of room
air, and an increase in the ventilation efficiency, including the elimination of
nasopharyngeal dead space, positive end-expiratory pressure (PEEP) effects, and improvements
in paradoxical abdominal movement. Regarding the effects on lung volume, global ventilation
in the lungs increases during HFNC, which is thought to attribute to PEEP effects. However,
how regional ventilation is affected during HFNC in comparison with conventional NC remains
unknown.
Because PEEP in mechanically ventilated patients improves the regional homogeneity of
ventilation, investigators postulated that HFNC via PEEP effects would result in more
homogeneous regional distributions in the ventilation changes. Investigators therefore
assessed global and regional ventilation in patients with hypoxia receiving care via HFNC
using electric impedance tomography and compared these results with conventional nasal
cannula.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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