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Clinical Trial Summary

This study aims to assess the effect of two drugs for the treatment of chronic mountain sickness in highlanders.


Clinical Trial Description

About 100 million individuals reside at high altitude (>2500m) worldwide, with the largest populations of highlanders being found in South America (Andean), central Asia (Tibetan and Sherpa) and East Africa (Ethiopian). Despite unique adaptations to hypoxia in these populations, chronic mountain sickness (CMS) is a clinical syndrome which is observed in 5-33% of individuals residing permanently at high altitude.Several pharmacological approaches have been proposed in the treatment of EE and CMS. However, few studies show sufficient clinical evidence for safety and efficacy in CMS treatment and most highlanders with CMS remain untreated. The present project aims to better characterize chronic hypoxic responses in highlanders and to evaluate the interest of acetazolamide and statins as potential treatments for chronic mountain sickness. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04251364
Study type Interventional
Source Centre d'Expertise sur l'Altitude EXALT
Contact Samuel Verges, PhD
Phone 0476766860
Email sverges@chu-grenoble.fr
Status Recruiting
Phase N/A
Start date February 15, 2020
Completion date December 30, 2021

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