Septic Shock Clinical Trial
Official title:
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the relationship between PIVA and intravenous volume administration during resuscitation of infected patients with presumed hypovolemia; and, the relationship between PIVA and volume decreases during diuresis in acute heart failure patients with hypervolemia.
The determination of volume status remains a clinical challenge in medicine. Patients may
develop hypovolemia (too little fluids in the vascular space) due to conditions such as
hemorrhage, dehydration, or infection with vascular leak. Alternatively, patients may become
hypervolemic (too much fluids in the vascular space), due to conditions such as heart
failure, renal failure, or iatragenic over-resuscitation all of which overwhelm the kidney's
ability to regulate intravascular volume status. In clinical practice, clinicians strive to
return patients to euvolemia (the "right" volume status) through the administration of
intravenous fluids or diuretics which remove fluids to achieve homeostasis. While there are a
number of proposed clinical exam findings (e.g. dry mucous membranes or skin turgor),
measurements (e.g. central venous pressure), or laboratory tests (e.g. blood urea nitrogen),
none are precise or universally accepted as reliable methodologies to assess volume status.
The goal of this study is to perform a prospective observational study on three distinct
cohorts during ED presentation to assess the variability and performance of PIVA in tracking
volume status.
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