Hypotension in Children With Down Syndrome With Anesthesia Induction

Status Completed

Clinical Trial Summary

Children generally undergo induction of anesthesia by inhalation of sevoflurane. Children with Down Syndrome experience bradycardia with induction of anesthesia using sevoflurane. It is unknown if this bradycardia is isolate or results in hypotension, thus requiring treatment. Isolate bradycardia without hypotension does not require treatment and should be avoided as many of these patients have underlying cardiac anomalies.

Clinical Trial Description

Children generally undergo induction of anesthesia by inhalation of sevoflurane. This is particularly relevant for children with developmental delays as to avoid placement of an IV while awake. However, children with Down Syndrome experience bradycardia with induction of anesthesia using sevoflurane. It is unknown if this bradycardia is isolate or results in hypotension, thus requiring treatment. Isolate bradycardia without hypotension does not require treatment and should be avoided as many of these patients have underlying cardiac anomalies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04603469
Study type	Observational
Source	Baylor College of Medicine
Contact
Status	Completed
Phase
Start date	May 26, 2021
Completion date	October 28, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05497700` - Comparative Efficacity of Ephedrine Versus Norepinephrine to Correct Anesthesia Induction Related Hypotension	Phase 3
Not yet recruiting	`NCT03580590` - Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery	Early Phase 1
Completed	`NCT04573842` - Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Induction
Recruiting	`NCT06426784` - Perfusion Index as a Predictor of Hypotension Following Sub-arachnoid Block Among Patients Undergoing Lower Segment Caesarean Section
Recruiting	`NCT05891951` - Effect of Carotid Ultrasound-guided Fluid Management on Anesthetic-induced Hypotension in Elderly Patients Undergoing Gastrointestinal Surgery	N/A
Completed	`NCT05842759` - Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study	N/A
Recruiting	`NCT05884918` - Intraoperative Hypotension in High-risk Patients Undergoing Surgery
Completed	`NCT05239234` - Ultrasonographic Predictors of Hypotension After Induction
Not yet recruiting	`NCT04291794` - Mean Arterial Pressure Reduction Anesthesia Induction Using Propofol Bolus or Tritiated Target-infusion	Phase 4
Completed	`NCT04051073` - Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.	Phase 3
Completed	`NCT01669434` - Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery	Phase 4
Completed	`NCT05424510` - PoCUS Guided Fluids to Prevent Post-induction Hypotension	N/A
Recruiting	`NCT05969886` - Ventricular-Arterial Coupling: A Predictor of Post-Induction Hypotension
Not yet recruiting	`NCT05536323` - Bolus Versus Continuous Remimazolam for Anesthetic Induction	N/A
Recruiting	`NCT03237429` - The Relationship Between BCM, Arterial Stiffness and Hemodynamic Instability During Induction of General Anesthesia
Withdrawn	`NCT04299776` - CirQPOD Shoulder Study	N/A
Completed	`NCT03439007` - Anesthesia-induced Hypotension and Fluid Responsiveness
Completed	`NCT03787732` - Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation	Phase 4
Not yet recruiting	`NCT05960604` - Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Completed	`NCT04658576` - Pre-operative Ultrasonographic Evaluation of Caval Aorta Diameter Index as a Predictor for Post-induction Hypotension