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Hypoparathyroidism clinical trials

View clinical trials related to Hypoparathyroidism.

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NCT ID: NCT05214274 Completed - Clinical trials for Chronic Hypoparathyroidism

Multicenter Registry Study of Chronic Hypoparathyroidism in Chinese Adults

PaTHwayR
Start date: January 10, 2022
Phase:
Study type: Observational

This multicenter registry study aims to understand the status of diagnosis and treatment, quality of life, medical costs and unmet medical needs of adult patients with chronic hypoparathyroidism in China.

NCT ID: NCT05186883 Not yet recruiting - Clinical trials for Postoperative Hypoparathyroidism

Treatment of Postoperative Hypoparathyroidism Using Cultured Allogenic Parathyroid Cells

Start date: March 1, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

The idea of the project is to develop a method of treatment of postoperative hypoparathyroidism using cultured allogenic parathyroid cells.

NCT ID: NCT05130476 Active, not recruiting - Clinical trials for Hypoparathyroidism Postprocedural

Near-infrared Imaging Techniques for Identifying and Preserving Viable Parathyroid Glands During Thyroidectomy

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

The parathyroid glands and their blood vessels are notoriously difficult to visualize and may therefore be unintentionally and irrevocably damaged during thyroid surgery. This project investigates new surgeon-performed imaging techniques that visualize the parathyroid glands and their vessels in real-time during thyroid surgery. The purpose is to examine, in a matched cohort study, whether the implementation of near-infrared-induced autofluorescence for identification of the parathyroid glands, combined with indocyanine green near-infrared angiography of the parathyroid feeding vessels, can reduce the incidence of postoperative hypocalcaemia in patients undergoing total and completion thyroidectomy at Odense University Hospital.

NCT ID: NCT05117853 Recruiting - Thyroid Disease Clinical Trials

Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Thyroidectomy

Start date: November 1, 2021
Phase: Phase 3
Study type: Interventional

- Hypoparathyroidism (and the resulting hypocalcemia) remains the most common morbidity after a total thyroidectomy. - The identification and preservation of parathyroid glands during neck surgery has always been challenging but is crucial to avoid postoperative hypocalcemia. - Recently, the specific autofluorescent characteristics of endogenous fluorophores in the parathyroid tissue have been used to detect and confirm parathyroid glands during thyroid surgery. - Injecting indocyanine green and using its fluorescent characteristics has the advantage of adding information about the vascular supply of the parathyroid glands. - This randomized clinical trial aims to investigate whether using autofluorescence and indocyanine green during thyroid surgery can predict or prevent postoperative hypocalcemia.

NCT ID: NCT05114980 Recruiting - Hypoparathyroidism Clinical Trials

Parathyroid Allotransplantation in Medically Refractory Hypoparathyroidism

PATH
Start date: July 2024
Phase: N/A
Study type: Interventional

Options for treatment of severe, refractory hypocalcemia are limited for the thousands of patients in the United States who suffer from hypoparathyroidism. Parathyroid allotransplantation is an emerging treatment that provides hope for these individuals. Currently, this therapy has only been successfully provided by a few centers in the world. In the UAB PATH trial, we propose to become one of the few centers worldwide to successfully achieve parathyroid allotransplantation in transplant-naïve patients.

NCT ID: NCT05043584 Completed - Hypoparathyroidism Clinical Trials

Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions

Start date: September 15, 2021
Phase: N/A
Study type: Interventional

Hypoparathyroidism is the most frequent complication in total thyroidectomy. The use of near-infrared autofluorescence (NIRAF) intraoperatively, seems to reduce the rate of transient hypoparathyroidism. Unfortunately, no effect on permanent hypoparathyroidism has been shown. In order to cover every aspect of the impact of NIRAF in thyroid surgery, an evaluation in low-volume, non-parathyroid institutions is needed. This is the overall aim of our current studies. The objective of this specific study is to evaluate the impact of NIRAF on immediate, transient and permanent hypoparathyroidism following total thyroidectomy in low-volume, non-parathyroid institutions.

NCT ID: NCT05022667 Recruiting - Neoplasms Clinical Trials

Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

This study will see if the use of near infrared autofluorescence (NIRAF) detection with a 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during total thyroidectomy (TTx) is better than surgeon's detection alone. It compares risk, benefits and outcomes in TTx patients where NIRAF detection with PTeye for parathyroid identification is either used or not used.

NCT ID: NCT04998968 Enrolling by invitation - Clinical trials for Permanent Hypoparathyroidism

Quality in Patients With Permanent Hypoparathyroidism After Total Thyroidectomy

Start date: September 1, 2021
Phase:
Study type: Observational

Quality of life study. The study with include all patients operated with total thyroidectomy between 2005-2015 in Uppsala-Örebro healthcare region, Sweden. The study population has been identified in a previous study and includes close to 1700 patients, of which about 200 developed permanent hypoparathyroidism after surgery. Quality of Life will be assessed using SF-36 Health Surgery and the outcome for patients with and without permanent hypoparathyroidism will be compared.

NCT ID: NCT04785443 Recruiting - Thyroid Diseases Clinical Trials

Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy

HYPOCAAVI
Start date: June 22, 2021
Phase: Phase 3
Study type: Interventional

- Hypoparathyroidism is the most common complication after a total thyroidectomy surgery. It becomes permanent after 6 months. - Untreated permanent hypoparathyroidism is a source of numerous complications in general and therefore requires lifelong replacement therapy resulting in a significant deterioration in quality of life. - The intraoperative use of indocyanine green (ICG) angiography has recently been described as a reliable means of detecting parathyroidism and predicting the risk of postoperative hypoparathyroidism. - This use could prove to be a way to preserve parathyroid in vivo and thus reduce post-operative hypoparathyroidism rates.

NCT ID: NCT04750460 Completed - Clinical trials for Secondary Hyperparathyroidism

Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).

TeriCa
Start date: March 1, 2021
Phase: Phase 3
Study type: Interventional

This is a pilot randomized controlled trial aimed to evaluate the effect of teriparatide on the clinical course of hypocalcemia after parathyroidectomy for secondary hyperparathyroidism in dialysis-dependent patients.