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Clinical Trial Summary

The idea of the project is to develop a method of treatment of postoperative hypoparathyroidism using cultured allogenic parathyroid cells.

Clinical Trial Description

The cells will be isolated and cultured from the parathyroid gland of brain-dead organ donors. Cells will be tested for the immunophenotype, viability, sterility and the production of parathyroid hormone. Cells will be co-cultured with the patients T-cells and the expression of perforin and granzyme B proteins will be assayed as well as the apoptosis/viability of parathyroid cells. Prepared cells will be used to treat the patients with postoperative hypoparathyroidism. The safety, tolerability and clinical efficacy will be studied. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05186883
Study type Interventional
Source Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Contact Andrei Hancharou, Dr
Phone +375296248972
Email [email protected]
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date March 1, 2022
Completion date December 31, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT04281875 - Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy. N/A