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Hypertonia, Muscle clinical trials

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NCT ID: NCT06117020 Recruiting - Stroke Clinical Trials

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Start date: September 11, 2023
Phase: Phase 1
Study type: Interventional

To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601. To evaluate the pharmacodynamic (PD) effects of MTR-601 on muscle strength and muscle accumulation of MTR-601 by muscle biopsy and other potential mechanistic, predictive and PD markers of MTR-601.

NCT ID: NCT05527652 Recruiting - Clinical trials for Obstructive Sleep Apnea

Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

Start date: November 16, 2022
Phase: N/A
Study type: Interventional

The researchers are investigating if the Self-Supporting Nasopharyngeal Airway (ssNPA) device can be used in the treatment of obstructive sleep apnea in children with Hypotonic Upper Airway Obstruction (HUAO).

NCT ID: NCT04188769 Withdrawn - Stroke Clinical Trials

Effect of Local Pressure on Muscle Activity and General Relaxation in Persons With Hypertonia Following Stroke

Start date: December 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effect of - both constant as intermittent - local application of deep pressure on muscle activity and general relaxation in persons with hypertonia following stroke.

NCT ID: NCT03492060 Recruiting - Clinical trials for Autism Spectrum Disorder

A Natural History Study of hnRNP-related Disorders

Start date: June 13, 2018
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to analyze patterns in individuals with hnRNP (and other) genetic variants, including their neurological comorbidities, other medical problems and any treatment. The investigators will maintain an ongoing database of medical data that is otherwise being collected for routine medical care. The investigators will also collect data prospectively in the form of questionnaires, neuropsychological assessments, motor assessments, and electroencephalography to examine the landscape of deleterious variants in these genes.