Biomarkers to Assess Acute Kidney Injury Risk During Heat Strain

Status Withdrawn

Clinical Trial Summary

Prolonged, high intensity work in a hot environment results in significant strain on the body, known as heat strain. Heat strain in hot occupational settings such as agriculture, fire suppression, and military work can lead to ~20% of workers exceeding the glomerular filtration rate indicated thresholds for acute kidney injury (AKI). However, it is unclear whether these individuals truly experienced AKI or if these were normal, healthy physiologic responses. To better determine if AKI occurs in the staggering number of workers previously reported, AKI biomarkers are needed in addition to kidney function markers (e.g., glomerular filtration rate) to characterize this response. The product of urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) is a promising Food and Drug Administration approved biomarker indicating risk of AKI and is currently used in hospitalized individuals. The usefulness of this biomarker in determining AKI in healthy individuals during heat strain is now beginning to be understood. Consecutive days of heat strain can result in repeated AKI, which is hypothesized to lead to chronic kidney disease. There is an epidemic of chronic kidney disease of non-traditional causes occurring in workers who undergo repeated days heat strain, including approximately 15% of outdoor workers in Central America. Of the few studies that investigated consecutive days of work in the heat, we demonstrated that participants exceed the glomerular filtration rate indicated threshold for AKI during consecutive days of heat strain. This project will determine whether [TIMP-2 x IGFBP7] increases during occupational relevant heat exposures in a healthy, active population. Additionally, this project will compare the impact of repeated exposures to a hot environment on risk of AKI.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05710978
Study type	Interventional
Source	State University of New York at Buffalo
Contact
Status	Withdrawn
Phase	N/A
Start date	October 13, 2022
Completion date	November 8, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04431596` - Military Alerting System for Monitoring Body Temperature During Active Cooling	N/A
Completed	`NCT05601713` - Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling	N/A
Completed	`NCT00940654` - The Fever and Antipyretic in Critically Illness Evaluation Study	N/A
Recruiting	`NCT05809453` - Intranasal Cocaine and Temperature Regulation During Exercise	Phase 1/Phase 2
Completed	`NCT04915859` - Semiconductor Heat Extraction Cooling	N/A
Completed	`NCT04613843` - Cold Water Immersion Stirring in Hyperthermic Individuals	N/A
Completed	`NCT03689478` - Use of Immediate Hyperthermic Intravesical Chemotherapy Following TURBT	N/A
Completed	`NCT02271607` - The Effect and Safety of Moxibustion Therapy for Overactive Bladder Patients	N/A
Terminated	`NCT01963117` - Effectiveness of the Combined WLI and Hyperthermia for GI Cancer Liver Metastasis	N/A
Completed	`NCT04596618` - Impact of ICE on Exercise Performance in the Heat	N/A
Completed	`NCT05586477` - Diphenhydramine and Sweating	Phase 4
Completed	`NCT01576822` - Sauna Detoxification Study: Pilot Feasibility	Phase 1
Recruiting	`NCT05366270` - Peripheral Neuroimmune Mechanisms of Hyperthermia	N/A
Recruiting	`NCT05993910` - Prospective Hyperthermia Database in Cancer Patients (HT Register)
Terminated	`NCT04104334` - Impact of an Optimised Monitored Anesthesia on the Patients' Recovery After Cytoreduction Surgery Plus HIPEC	N/A
Not yet recruiting	`NCT05274009` - Protective Cooling Measures to Safeguard Elderly People From Dangerous Summer Heat	N/A
Terminated	`NCT00796900` - Dantrolene for Treatment of Hyperthermia in Subarachnoidal Hemorrhage (SAH)	Phase 2/Phase 3
Active, not recruiting	`NCT02546596` - The Effect of Electro-Hyperthermia in Preoperative Radiotherapy for Locally Advanced Rectal Cancer	N/A
Completed	`NCT05327764` - Work-To-Rest Ratios	N/A
Completed	`NCT04767347` - Renal Considerations in the Heat Stress Recommendations	N/A