Hypertensive Disorder of Pregnancy Clinical Trial
Official title:
HyperAldosteronism in Pregnancy Predicted Impacts
Primary hyperaldosteronism confers a higher risk of cardiovascular complications compared to essential hypertension. Preliminary data is controversial in regards of excessive maternal fetal and neonatal excessive risks in pregnancy. This study aims at establishing the prevalence of PHA in an population with a recent episode of hypertensive disorder of pregnancy (HDP). The goal is to determine if a universal screening for PHA after a HDP is worthed. The investigators also wish to evaluate the complication rate in pregnant women with PHA compared to women without PHA. This is a prospective cohort study where all eligible women will be screened for PHA after a HDP episode in the last pregnancy. We will then compare PHA women to non PHA women according to pregnancy complications.
This is a pilot study to evaluate feasibility and proof of concept. This is a prospective multicenter cohort study. Two university centers will participate (Sherbrooke and Montreal). Participants will be recruited from post-partum Obstetric Medicine clinic in two tertiary care centers. They will be included if they presented a hypertensive disorder of preganncy (HDP) in their last pregnacy (from 4 weeks to 24 months after delivery). Women with pheochromocytoma, Cushing syndrome, secondary hyperaldosteronism, and those who are currently pregnant will be excluded. All participants will be screened for PHA (with an aldosterone/renin ratio) and if the screening test is positive, they will be referred to a specialist to confirm the diagnosis. Data will be collected from the participants and their babies' charts. Demographic data, obstetrical data, delivery data, maternal/fetal/neonatal complications, and diagnostic of PHA data will be collected. A convenient sample size of 200 women will be used. If the prevalence of HPA is 5% or more, this would justify a larger study. Primary outcome: establish the prevalence of PHA in women with a hypertensive disorders of pregnancy in last pregancy. Secondary outcome include: 1. to compare maternal, fetal and neonatal outcomes among women diagnosed with primary hyperaldosteronism (PHA) and pregnant women without PHA. 2. to establish the prevalence of PHA for each sub-type of hypertensive disorder of pregnancy 3. to compare maternal, fetal and neonatal outcomes among women diagnosed with primary hyperaldosteronism (PHA) before pregnancy and pregnant women diagnosed with PHA after pregnancy. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05999851 -
Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
|
N/A | |
| Recruiting |
NCT05687344 -
Intensive Postpartum Antihypertensive Treatment
|
Phase 3 | |
| Recruiting |
NCT02020174 -
The Preeclampsia Registry
|
||
| Recruiting |
NCT06377878 -
The Preeclampsia Registry
|
||
| Recruiting |
NCT05995106 -
mHealth for Hypertensive Disorder of Pregnancy
|
N/A | |
| Completed |
NCT03309826 -
Positive Airway Pressure Treatment of Obstructive Sleep-disordered Breathing in Hypertensive Disorders of Pregnancy
|
N/A | |
| Completed |
NCT05631067 -
Feasibility and Acceptability of Risk Stratification in the Fourth Trimester to Reduce Maternal Morbidity and Mortality
|
N/A | |
| Completed |
NCT03412552 -
Risk Analysis of Intensive Care Mangement on Maternal and Fetal Outcome of Severe Preeclampsia and Eclampsia
|
N/A | |
| Completed |
NCT03728790 -
Remote BP Monitoring in the PP Period
|
N/A | |
| Recruiting |
NCT05089175 -
The Investigation of the Prediction Model and Prevention Strategy of Serious Pregnancy Complications in Hypertensive Disorders of Pregnancy Based on the Chinese Population
|
||
| Enrolling by invitation |
NCT05763069 -
HOME: Home Monitoring of High-risk Pregnancies
|
||
| Recruiting |
NCT06069102 -
Optimal Blood Pressure Treatment Thresholds Postpartum
|
Phase 4 | |
| Recruiting |
NCT05659173 -
Vitamin D Deficiency With Selected Vitamin D Receptor Gene Polymorphism in Gestational Hypertension
|
||
| Recruiting |
NCT06281665 -
Treatment With Aspirin After Preeclampsia: TAP Trial
|
Phase 4 | |
| Completed |
NCT05124327 -
Remote Monitoring and Follow-up for Postpartum Hypertensive Disorders of Pregnancy
|
N/A | |
| Recruiting |
NCT06362356 -
Microbial Metabolites and Outcomes of Pregnancy Study
|
||
| Active, not recruiting |
NCT04580927 -
Breastfeeding and Postpartum Cardiovascular Health
|
N/A | |
| Recruiting |
NCT05655936 -
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
|
N/A | |
| Enrolling by invitation |
NCT05835596 -
MumCare: Mum's Cardiovascular Health for Life
|
N/A | |
| Completed |
NCT06019715 -
Remote Postpartum Intervention Targeting Movement Behaviors After Hypertensive Disorders of Pregnancy
|
N/A |