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Pharmacogenetics of Torasemide and Spironolactone in Hypertension Treatment — ALTUM  

Hypertension Clinical Trial

Official title:
Pharmacogenetics of Hypertension: a Single-centre Randomized Study in Patients With Essential Hypertension Treated With Spironolactone or Torasemide

Clinical Trial Summary

Phase III interventional study to evaluate the different efficacy of Torasemide and Spironolactone in reducing systolic blood pressure in carriers and non-carriers of the different genotypic combinations for Lanosterol and Uromodulin

Clinical Trial Description

The investigators will enroll 144 naïve hypertensive subjects who will undertake 2-4 weeks of run-in and 4 weeks of treatment (7 day window at each visit). During this period partecipants will follow a low sodium diet (about 5g/day) and will be monitored with blood chemistry tests ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06413082
Study type Interventional
Source Ospedale San Raffaele
Contact
Status Completed
Phase Phase 3
Start date February 15, 2021
Completion date September 3, 2023
View Details
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