| Eligibility |
Inclusion Criteria:
1. Healthy adults aged between 19 to 55 years at the time of screening.
2. Individuals who had 18.0 kg/m2 = Body Mass Index (BMI) < 30.5 kg/m2 and whose body
weight was = 55 kg.
? BMI = weight(kg) / height(m)2
3. Individuals without congenital/chronic diseases and without abnormal symptoms or
diagnosis based on a medical examination within the last 3 years.
4. Individuals who were deemed to be appropriate as study subjects according to the
laboratory tests (hematology, blood chemistry, urinalysis, serology, etc.), vital
signs, 12-lead electrocardiogram (ECG), etc., performed at screening.
5. Individuals who signed an informed consent form approved by the Institutional Review
Board (IRB) of Jeonbuk National University Hospital and who decided to participate
voluntarily in the study after being fully informed of the study objective, contents,
etc. prior to participation.
6. Individuals who consented to the use of reliable contraception (contraceptive methods
other than hormones: use of condoms, intrauterine devices (IUD, IUS), tubal ligation,
cervical cap, contraceptive diaphragm, etc.) during the clinical trial and not to
donate sperm until 1 month after the last administration of investigational
product(s).
7. Individuals with the ability and willingness to participate the entire study period.
Exclusion Criteria:
1. Individuals with medical evidence or a history (excluding a simple dental history of
dental calculus, impacted tooth, wisdom tooth, etc.) of clinically significant
hematological, renal, endocrine, respiratory, gastrointestinal(Active gastric ulcer),
duodenal ulcer, etc.), urinary, cardiovascular (severe aortic valve stenosis,
aArterial valve, mitral valve stenosis, obstructive hypertrophic cardiomyopathy,
etc.), hepatic (severe hepatic impairment, etc.), psychiatric, neurologic, or immune
diseases.
2. Individuals with a medical history of gastrointestinal diseases (e.g., esophageal
disorders such as esophageal achalasia or esophagostenosis, Crohn's disease) or
operations (excluding simple appendectomy, herniotomy, or tooth extraction) that may
affect drug absorption.
3. Individuals with the following laboratory test result at screening:
- ALT or AST > 2x the upper limit of the normal range
- CK > 3x the upper limit of the normal range
- eGFR <60 mL/min/1.73 m2 using CKD-EPI formula
4. Individuals with a history of regular alcohol consumption exceeding 210 g/week within
6 months prior to screening (1 drink (250 mL) of beer (5%) = 10 g; 1 drink (50 mL) of
hard liquor (20%) = 8 g; 1 drink (125 mL) of wine (12%) = 12 g).
5. Individuals who smoked more than 20 cigarettes per day within 6 months prior to
screening.
6. Individuals who had taken investigational product(s) from other clinical trials or
bioequivalence studies within 6 months prior to the first administration of the
investigational product(s).
7. Individuals with the following vital signs upon screening
? Systolic blood pressure =140 mmHg or <90 mmHg and/or a diastolic blood pressure =90
mmHg or <60 mmHg in sitting position.
8. Individuals with a medical history of significant alcohol or drug abuse within 1 year
prior to the screening.
9. Individuals who had taken any drug(s) known as a strong inducer(s) or inhibitor(s) of
drug-metabolizing enzymes within 30 days prior to the first administration of the
investigational product(s).
10. Individuals who had taken prescription or nonprescription drugs within 10 days prior
to the first administration of the investigational product(s).
11. Individuals who donated whole blood within 2 months or blood components within 1 month
or have given blood transfusion within 1 month prior to the first administration of
the investigational product(s).
12. Individuals with severe acute/chronic medical or psychological conditions, whose
participation in the clinical trial and administration of the investigational products
could increase the risk to the subjects or interfere with the interpretation of trial
results.
13. Individuals with hypersensitivity to the investigational product(s), components of the
investigational product(s), or dihydropyridine drugs, thiazide diuretics, or
sulfonamide drugs, or hereditary issues of intolerance etc.
14. Patients with hereditary angioedema or with a history of angioedema when treated with
ACE inhibitors or angiotensin II receptor antagonists.
15. Patients with shock.
16. Patients with anuria.
17. Patients with biliary obstructive disease.
18. Patients with diabetes or moderate to severe renal impairment who use
aliskiren-containing preparations in combination.
19. Patients with severe heart failure.
20. Patients with Hypokalemia.
21. Patients with hyponatremia, hypercalcemia.
22. Patients with Hyperuricemia (with gout or uric acid stone).
23. Patients with Addison's syndrome.
24. Patients receiving lithium therapy.
25. Patients taking terfenadine or astemizole (can cause QT prolongation and ventricular
arrhythmias).
26. Women who are pregnant or lactating.
27. Individuals who were deemed inappropriate to participate in the study by the
investigator.
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