Hypertension, Pulmonary Clinical Trial
Official title:
Assessment of Recovery of Functional Capillary Surface Area in Patients Undergoing a Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Chronic thromboembolic pulmonary hypertension [CTEPH] is caused by pulmonary emboli that have enlarged in pulmonary arteries and have become organized into the vessel wall. Many patients with CTEPH are treated with balloon pulmonary angioplasty [BPA] which mechanically opens the narrow pulmonary arteries. It is unclear how much downstream functional pulmonary capillary surface area [FCSA] is recovered during BPA. We plan to measure FCSAIn CTEPH patients, before and after a session of BPA.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | January 30, 2025 |
Est. primary completion date | January 30, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - All patients eligible for balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension Exclusion Criteria: - Treatment with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, Presence of patent foramen ovale |
Country | Name | City | State |
---|---|---|---|
Canada | David Langleben | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Jewish General Hospital |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Increase in pulmonary functional capillary surface area | Measurement of transpulmonary metabolism of benzoyl-Phe-Ala-Pro | 4 hours |
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