Clinical Trial Details
— Status: Terminated
Administrative data
NCT number |
NCT05295758 |
Other study ID # |
IRB-22-01-4343 |
Secondary ID |
|
Status |
Terminated |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
November 18, 2022 |
Est. completion date |
January 25, 2024 |
Study information
Verified date |
June 2024 |
Source |
Wayne State University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health Inequities by
Early PreVEntion in the GREAT LakEs Region) Center (IRB 100221MP2A), the purpose of which is
to reduce cardiometabolic health disparities and downstream Black-White lifespan inequality
in two cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center will
involve three separate but related projects that aim to mitigate health disparities in risk
factor control for three chronic conditions, hypertension (HTN, Project 1), heart failure
(HF, Project 2) and coronary heart disease (CHD, Project 3), which drive downstream lifespan
inequality. All three projects will involve the use of Community Health Workers (CHWs) to
deliver an evidence-based practice intervention program called PAL2. All three projects will
also utilize the PAL2 Implementation Intervention (PAL2-II), which is a set of structured
training and evaluation strategies designed to optimize CHW competence and adherence (i.e.,
fidelity) to the PAL2 intervention program. The present study is Project 1 of the ACHIEVE
GREATER Center
Description:
Hypertension (HTN) is the leading risk factor for global morbidity and mortality, accounting
for a significant proportion of atherosclerotic cardiovascular disease (CVD), heart failure
and chronic kidney disease. Even mild elevations in blood pressure (BP) are harmful whereby
individuals with stage 1 HTN (130-139/80-89 mm Hg) are already at double CVD risk.
Accordingly, the latest HTN guidelines advocated for earlier treatment to reduce the health
consequences and prevent the progression to more severe stages which further increases CVD
risk. While nearly half of all Americans have HTN, Black adults suffer from a higher
prevalence, worse control rates, and more frequent adverse health effects. They are also at
heightened risk for an earlier and accelerated progression from mild to more severe HTN.
Unfortunately, little progress has been made over past decades in mitigating health
inequities related to high BP. In fact, predominantly Black cities such as Detroit
disproportionately suffer from nearly twice the national average mortality rate due to CVD.
Mounting evidence shows that pervasive negative social determinants of heath (SDoH) are major
drivers of these inequities and represent a critical barrier to achieving BP control in Black
hypertensives. Core issues include poor access to healthcare and a burdensome system for care
linkage especially in under-resourced settings, low health education and literacy, and
structural inadequacies in care delivery including a failure to address the spectrum of life
circumstances that elevate BP and hinder the adoption of salutary lifestyle changes. These
systemic issues must be addressed, and remedied early in the hypertension disease process, if
the health burden and CVD sequela of high BP are to be successfully reduced in Black
communities. To address parallel racial inequities related to COVID-19 in Detroit, we
developed an innovative mobile health unit (MHU) program that uses geospatial health and
social vulnerability data to target deployment of specially outfitted vehicles to
predominately Black communities with the highest needs. Since April 2020, Wayne Health Mobile
Unit conducted 550 events with 220 community partners where 45,000 people have been
vaccinated or tested for COVID.
In PROJECT 1 (ACHIEVE HTN), of the ACHIEVE GREATER (Addressing Cardiometabolic Health
Inequities by Early Prevention in the Great Lakes Region) research center, the project
proposes an innovative approach to identify and control HTN at its earliest stages in
undiagnosed Black adults, potentially yielding an enormous benefit towards lifetime health
equity. Using a hybrid type I effectiveness-implementation and quasi-experimental design, we
will leverage our MHU platform to implement a program that links low CVD risk Black adults
with stage 1 HTN to collaborative care delivered by non-physicians, community health workers
(CHWs) and pharmacists, consisting of a personalized, adaptable approach to lifestyle and
life circumstance (PAL2) intervention for 12-months. Core features of PAL2 include the
ability to choose from a menu of readily available interventions that address individual
negative SDoH, culturally sensitive health and lifestyle education, and adaptability over
time according to its acceptance, effectiveness (reduction in home BP), and evolving patient
needs. If BP remains ≥130/80 mm Hg after 6 months, a pharmacist-directed medical treatment
algorithm will be added to PAL2 to achieve timely BP control. Program benefits, including
BP-lowering, will be assessed during implementation (12-months) and maintenance phases (year
2) after linkage to medical care.