Understanding Blood Pressure Changes After Birth

Status Recruiting

Clinical Trial Summary

Research Question How does maternal blood pressure respond in the postpartum period for women who had a hypertensive disorder in pregnancy? Aim To evaluate the recovery of maternal blood pressure after a pregnancy affected by new onset hypertension after twenty weeks gestation Objectives - To identify rates of persistent hypertension after pregnancies affected by HDP - To assess and compare the accuracy of HBPM against the gold standard of ABPM - To assess the maternal acceptance of HBPM and ABPM - To explore what CVD-related care information is provided at the 6-8 week GP appointment

Clinical Trial Description

This research aims to investigate how women's blood pressure responds after birth and assess the time it takes to return to normal ranges. This will be calculated by participants undertaking three consecutive days of home blood pressure monitoring, every fortnight from two until twelve weeks postpartum. At twelve weeks postpartum, women will have a twenty-four ambulatory blood pressure assessment. This will highlight the prevalence of persistent high blood pressure and how often GPs will need to monitor women's blood pressure in the immediate few weeks after birth. Women will be asked to complete a questionnaire after their six to eight week GP appointment, assessing if women recall having their blood pressure checked and/or the risks of heart disease explained to them and if they received any lifestyle advice to reduce these risks. Women will be asked to complete a second questionnaire at twelve weeks postpartum assessing their acceptance and preference of home and twenty four hour blood pressure monitoring. This research aims to identify any gaps in the current care of women in the postnatal period and use this information to provide better quality of care to women so they can lead healthier lives and reduce their risk of heart disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05137808
Study type	Observational
Source	St George's, University of London
Contact
Status	Recruiting
Phase
Start date	May 9, 2022
Completion date	December 31, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT00974714` - L-arginine Effects on Chronic Hypertension in Pregnancy	Phase 3
Terminated	`NCT03595982` - Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily?	Phase 4
Completed	`NCT04486170` - Assessment of Postpartum Education to Improve Compliance	N/A
Completed	`NCT03506724` - Response to Anti-hypertensives in Pregnant and Postpartum Patients	Phase 4
Completed	`NCT03613714` - Innovation in Postpartum Care for Women With Hypertensive Disorders of Pregnancy	N/A
Recruiting	`NCT04604535` - The BEET-BP Trial - Investigating the Effect of Dietary Nitrates on Hypertension in Pregnancy	N/A
Completed	`NCT00412230` - Insulin Resistance and Hypertensive Disorders in Pregnancy	N/A
Active, not recruiting	`NCT05049616` - Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension	Phase 4
Completed	`NCT04119232` - Randomized Clinical Trial to Increase Physical Activity After a a Hypertensive Pregnancy	N/A
Completed	`NCT04633551` - Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes	N/A
Completed	`NCT05859282` - Development and Validation of a Short Tool to Assess the Awareness of Pregnancy-induced Hypertension
Active, not recruiting	`NCT05543265` - Bridging the Gap From Postpartum to Primary Care	N/A
Completed	`NCT00571766` - Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy	Phase 3
Recruiting	`NCT05473767` - Expanding the Family Check-Up in Early Childhood to Promote Cardiovascular Health of Mothers and Young Children	N/A
Recruiting	`NCT05683093` - Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
Completed	`NCT06403722` - Perinatal Outcomes in Patients With Elevated sFlt-1/PlGF Ratio
Recruiting	`NCT05852054` - Supporting Transitions to Primary Care Among Under-resourced, Postpartum Women (STEP-UP)	Phase 3
Completed	`NCT03961360` - Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida	Phase 2/Phase 3
Active, not recruiting	`NCT03648645` - Hypertensive Pregnant Women Monitored by Teletransmitted Self-measurements of Blood Pressure	N/A
Recruiting	`NCT06054841` - Reshaping Postpartum Follow-up	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.