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Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

Hypertension Clinical Trial

Official title:
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study

Clinical Trial Summary

This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high blood pressure and increase the risk of heart and kidney disease. Treatment with medications that block aldosterone can reduce that risk. This study is trying to learn whether treatment with a medication that blocks aldosterone can improve heart function in people who make too much aldosterone.

Clinical Trial Description

The study evaluates the impact of 6 months of treatment with the mineralocorticoid receptor blocking medication eplerenone on the heart's blood flow, using a cardiac PET stress test, and on the heart's structure and function by echocardiogram. Participants with a confirmed diagnosis of primary aldosteronism will undergo echocardiogram and cardiac PET stress test before and after 6 months of eplerenone treatment. Participants without a confirmed diagnosis of primary aldosteronism but with hypertension and a recent clinical PET test and echocardiogram will undergo testing to make the diagnosis of primary aldosteronism. Those who test positive will go on to treatment with eplerenone for 6 months, followed by a cardiac PET scan and echocardiogram. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05030545
Study type Interventional
Source Brigham and Women's Hospital
Contact Jenifer M Brown, MD
Phone 8573071990
Email jbrown35@bwh.harvard.edu
Status Recruiting
Phase Phase 4
Start date December 15, 2022
Completion date February 28, 2027
View Details
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