SHAPE of Portal Hypertension in Children

Status Recruiting

Clinical Trial Summary

Early diagnosis of portal hypertension is difficult as symptoms rarely manifest until the later stages of liver disease. Both cirrhotic and non-cirrhotic portal hypertension can result in life-threatening complications, the most frequent of which is bleeding from esophageal varices. In children, variceal bleeds are associated with mortality rates of 1-3 %, while life-threatening complications have been reported in up to 20 % of children with cirrhosis. Despite the high incidence of portal hypertension in children with liver disease, a noninvasive modality to monitor disease progression and risk of complications is currently lacking. Hence, this trial will investigate the safety and efficacy of subharmonic aided pressure estimation (SHAPE) as a noninvasive ultrasound technique for diagnosing portal hypertension in children.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04720456
Study type	Interventional
Source	Thomas Jefferson University
Contact	Morgan L Gabbert, MA
Phone	267-426-0820
Email	gabbertm@email.chop.edu
Status	Recruiting
Phase	Phase 2
Start date	November 3, 2021
Completion date	August 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03713606` - Serum Biomarkers for Portal Hypertension in Cirrhosis (Pan-CHESS1802)
Recruiting	`NCT02504034` - Interventional Radiology for the Treatment of Symptomatic Portal Hypertension in Patients With Cavernous Transformation of Portal Vein	N/A
Recruiting	`NCT02505152` - Percutaneous Transhepatic Intrahepatic Portosystemic Shunt for Treatment of Portal Vein Occlusion With Symptomatic Portal Hypertension After Splenectomy	N/A
Completed	`NCT02669875` - Serelaxin To Lower Portal Pressure	Phase 2
Completed	`NCT04645550` - Apixaban, Warfarin and Aspirin Prevents Portal Vein Thrombosis in Patients After Laparoscopic Splenectomy（ESAWAAPT）	Phase 4
Recruiting	`NCT02305914` - Follow-up Study of Complications of Acute Pancreatitis	N/A
Completed	`NCT01095185` - Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding	Phase 3
Terminated	`NCT05282121` - A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis or Non-alcoholic Steatohepatitis (NASH) Who Have High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)	Phase 2
Completed	`NCT00004641` - A Study to Prevent Complications of High Blood Pressure Caused by Hepatitis in Patients With Cirrhosis	Phase 2
Completed	`NCT03138915` - Radiomics Signature of Hepatic Venous Pressure Gradient (rHVPG) With CT Angiography (CHESS1701)	N/A
Completed	`NCT03175731` - PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)	Phase 4
Active, not recruiting	`NCT04315571` - Comparing Ascites Relief In Two Standard Treatments: Large Volume Paracentesis Vs. Early Tips Using Viatorr Controlled Expansion Stents	N/A
Completed	`NCT03459378` - Outcome After TIPS
Recruiting	`NCT03470389` - Establishment and Assessment of the HVPG Using Biofluid Mechanics (HVPGBFM)	N/A
Completed	`NCT02462967` - Clinical Trial to Evaluation the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis	Phase 2
Active, not recruiting	`NCT01097811` - Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy	N/A
Terminated	`NCT06082843` - A Study to Test Whether Avenciguat Helps People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver) Who Had Bleeding in the Esophagus or Fluid Accumulation in the Belly	Phase 2
Recruiting	`NCT03315767` - Spleen-ARFI-assisted-Portal-Hypertension-Evaluation-Study (SAPHES)	N/A
Terminated	`NCT05161481` - A Study to Test Whether Two Different Doses of Avenciguat Help People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Live	Phase 2
Completed	`NCT03766880` - MR-based Models for Clinically Significant Portal Hypertension in Cirrhosis (CHESS1802)	N/A