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Detection of Subclinical Cerebral Suffering Related to Hypertension Using Multimodal MRI — SOUCHY  

Hypertension Clinical Trial

Official title:
Detection of Subclinical Cerebral Suffering Related to Hypertension Using Multimodal MRI (SOUCHY) Brain Changes Due to Hypertension: a Multimodal MRI

Clinical Trial Summary

Investigators propose here to study the brain consequences of hypertension in patients without cognitive complaints and neurological signs. The evaluation of brain suffering requires considering various possible brain damage. The team developed a multimodal MRI approach capable of detecting and quantifying numerous indices (e.g. morphometric, microstructural) to evaluate possible brain suffering. This project aims to identify individually signs of cerebral suffering in hypertensive patients compared to a population of normotensive volunteers, using advanced multiparametric MRI methods.

Clinical Trial Description

Hypertension is a risk factor for many brain pathologies, such as ischemic and hemorrhagic neurodegenerative diseases or stroke. The literature seems to agree on the relationship between hypertension and brain damage, and on the benefit of the management of hypertension to prevent certain neurological pathologies. However, to our knowledge, no single study has shown signs of subclinical brain damage in patients with hypertension. At present, no brain MRI is recommended in these patients. In the present study, hypertensive and normotensive patients will undergo a neurological exam, a neuropsychological exam, a biological exam and a MRI exam to individually identify signs of cerebral suffering. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04642586
Study type Interventional
Source University Hospital, Toulouse
Contact Jean Darcourt, MD
Phone +33561775620
Email darcourt.j@chu-toulouse.fr
Status Recruiting
Phase N/A
Start date January 7, 2021
Completion date January 5, 2024
View Details
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