Hypertension Clinical Trial
Official title:
Short Term Effect of Empagliflozin on Left Ventricular Relaxation in Non Diabetic Hypertensive Patients
The investigators assessed the 6-week effect of once daily 25mg SGLT2-i Empagliflozin on left ventricular diastolic function and blood pressure profile in non diabetic hypertensive patients
Background: The rapid beneficial effects of Empagliflozin on cardiovascular mortality and
hospitalizations rates for heart failure according to the Cardiovascular Outcome Event Trial
in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial raise some question in the
mechanism of myocardial action. The investigators conducted this study in a population of
non-diabetic hypertensive patients in order to look for a short-term effect on left
ventricular relaxation.
Methods: The investigators carried out a single arm non- randomized clinical trial and
assigned patients to receive 25mg of empagliflozin once daily in additional therapy for six
weeks at the National Center for Obesity and in the cardiology department of Yaounde Central
Hospital in hypertensive patients with cardiac relaxation disorder. The objectives were to
evaluate the left ventricular diastolic function and nycthemeral blood pressure profile.
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