Hypertension Clinical Trial
Official title:
Association Between a Multi-Gene Panel and Renal Denervation Effectiveness in Patients With Hypertension
The purpose of this study is to assess the effectiveness of a multi-gene panel to determine which subjects are likely to respond to renal denervation therapy with Medtronic's Symplicity Spyral™ multi-electrode renal denervation system.
The objective of this study is to assess if renal denervation (RDN) effectiveness using the Symplicity SpyralTM multi-electrode renal denervation system is associated with ranked genomic scoring from the Geneticure multi-gene algorithm for renal denervation. The present study will assess if subjects who have a high genetic score, based on the hypothesized importance of the organ systems involved, will have differential responsiveness to RDN in a descending order. The genetic scoring is collectively ranked in a specific order, in that: - Subjects with a "high level of general functionality" (functionality in the sympathetic nervous system (SNS), cardiac, vascular (renin-angiotensin-aldosterone system (RAAS)), and renal system genotypes will be most responsive to RDN. - Subjects with high number of functional genotypes of SNS, cardiac, and RAAS will be the next most responsive group. - Subjects with functionality in genotypes of SNS and cardiac systems will demonstrate the next most responsive group. - Subjects with functionality in the SNS genotypes will demonstrate some degree of responsiveness. - Subjects with functionality in the renal system, but not SNS, cardiac, nor RAAS, will be the least responsive to this therapy. ;
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