Hypertension Clinical Trial
Official title:
The Effects of Pumpkin Seed Oil Supplementation on Vascular Hemodynamics, Stiffness and Cardiac Autonomic Function in Postmenopausal Women.
NCT number | NCT03716960 |
Other study ID # | 321 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | September 1, 2017 |
Est. completion date | June 30, 2018 |
Verified date | October 2018 |
Source | Marymount University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Postmenopausal women have a higher prevalence of cardiovascular (CV) disease than age-match
men. Growing evidence from rat studies have demonstrated CV-protective effects of pumpkin
seed oil (PSO).
The investigators hypothesis is that PSO would improve CV health in postmenopausal women.
Status | Completed |
Enrollment | 23 |
Est. completion date | June 30, 2018 |
Est. primary completion date | June 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 45 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Female - 45 to 65 years of age - At least 1 year after menopause - BMI <39.9 - Sedentary or low active (less than 2 hr per wk) Exclusion Criteria: - known heart disease - peripheral vascular disease - diabetes, body mass index - BMI> 40 kg/m2 - other chronic diseases - taking medications (e.g., hormone replacement therapy, beta blockers, calcium channel blockers, antidepressants and stimulants) that could affect the outcome variables - smokers - history of steady exercise or received exercise training and dietary changes in the last year |
Country | Name | City | State |
---|---|---|---|
United States | Marymount University | Arlington | Virginia |
Lead Sponsor | Collaborator |
---|---|
Marymount University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood pressure | Non-invasive measures of brachial and aortic blood pressure | 6 weeks | |
Primary | Pressure Wave Reflection | Using the augmentation index | 6 weeks | |
Primary | Arterial Stiffness | Using the stiffness index | 6 weeks | |
Primary | Heart rate variability | R-R intervals were collected during 6 min using a validated wireless monitor (Polar 800CX; Polar Electro OY, Kempele, Finland) via a chest strap interfaced with a PC. All R-R intervals were inspected for artifacts and premature beats. | 6 weeks |
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