Post-exercise Hypotension After a Power Training Session in Older Adults With Hypertension

Hypertension Clinical Trial

Official title:

Effect of a Power Training Session on Ambulatory Blood Pressure in Older Adults With Hypertension: a Randomized Crossover Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03615625
• Other study ID #: 85210618.1.0000.5327
• Status: Completed
• Phase: N/A
• Start date: June 12, 2018
• Est. completion date: January 1, 2020

Study information

• Verified date: January 2021
• Source: Hospital de Clinicas de Porto Alegre
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main purpose of the present study was to evaluate the effect of a power training session on office and 24h ambulatory blood pressure in older adults with hypertension. As secondary outcomes, the investigators compared post-exercise hypotension, BP variability, and endothelial function between older men and women with hypertension.

The working hypothesis was that a single bout of power exercise would decrease both office and 24 h BP in comparison to a non-exercising control session and men and women would respond differently after a power training session.

Description:

Participants randomly performed two experimental sessions: power exercise training (PT) and non-exercising control at seated rest (Con). They maintained their current antihypertensive medications throughout the trial. Each session was composed of 20 min of rest in the supine position, 40 min of PT or Con protocols, and 60 min of rest in supine position after protocols. The PT was composed of 3 sets of 8-10 repetitions of 5 exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50 % of 1-RM and two-minute intervals between sets and exercises. The concentric phase of exercises during each repetition was performed "as fast as possible" while the eccentric phase lasted 1-2 seconds. During the Con, the participants remained seated rest on the same exercise machines, but without any exercise. Standardized office BP was performed before and during the first hour (in intervals of 15 min) after exercise and control sessions. Together with the office BP evaluation in the pre and post sessions, the endothelium-dependent brachial vascular function was evaluated using Flow-mediated dilation. Afterwards, participants underwent 24h ambulatory BP monitoring..

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: January 1, 2020
• Est. primary completion date: July 20, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years to 75 Years

Eligibility

Inclusion Criteria:

• Office blood pressure between 130-179 and 80-110 mmHg for systolic and diastolic blood pressure, respectively;

• Non-engaged in structured programs of exercise for the last 3 months since the beginning of this study;

• Able to perform the proposed exercises.

Exclusion Criteria:

• Underlying cardiovascular disease previously diagnosticated by a doctor, occurred in the last 24 months, such as: acute myocardial infarction, angina, stroke or heart failure;

• Diseases that reduce life expectancy;

• Smokers and ex-smokers for less than six months;

• BMI > 39.9 kg/m²

• diabetic proliferative retinopathy.

Related Conditions & MeSH terms

• Hypertension

Intervention

Behavioral:
• Power Training Session
3 sets of 8-10 repetitions of 5 exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50 % of 1-RM and two-minute intervals between sets and exercises. The concentric phase of exercises during each repetition was performed "as fast as possible" while the eccentric phase lasted 1-2 seconds.

Locations

Country	Name	City	State
Brazil	Hospital de Clinicas de Porto Alegre	Porto Alegre	RS

Sponsors (2)

Lead Sponsor	Collaborator
Hospital de Clinicas de Porto Alegre	Federal University of Rio Grande do Sul

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Sex Differences in Ambulatory Blood Pressure Monitoring, Office Blood Pressure, Endothelial Function and Blood Pressure Variability		60 minutes and 24 hours after control and power training exercise session
Primary	Ambulatory Blood Pressure Monitoring	Mean 24-h, day-time, night-time of blood pressure in mmHg will be assessed after each experimental session (power training session and control session)	24 hours after control and power training exercise session
Secondary	Office Systolic Blood Pressure	Systolic blood pressure in mmHg will be measured using automatic oscillometric before and after each experimental session throughout one hour	60 minutes after control and power training exercise session
Secondary	Office Diastolic Blood Pressure	Diastolic blood pressure in mmHg will be measured using automatic oscillometric before and after each experimental session throughout one hour	60 minutes after control and power training exercise session
Secondary	Endothelial Function	Flow-mediated dilatation (FMD) assessed through high resolution ultrasonography before and after each experimental session throughout one hour	60 minutes after control and power training exercise session
Secondary	Blood Pressure Variability	Systolic and diastolic BP values obtained in the 24-hour ambulatory blood pressure monitoring, with valid measures included in a programmed software to calculate the average real variability of these measures.	24 hours after control and power training exercise session