Hypertension Clinical Trial
Official title:
Effects of Supplementation of Fruit Extract (Cranberry, Blueberry and Pomegranate) on Blood Pressure, Autonomic Balance, Insulin Resistance and Oxidative Stress in Hypertensive Patients
Verified date | January 2016 |
Source | University of Sao Paulo General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Recent evidence suggests that there is a directly proportional relationship between diets with a high concentration of antioxidants and the reduction of blood pressure and the risk of cardiovascular events. However, there is a gap with regard to research on the effects of these diets on vascular function, especially in humans. The aim of this study was to evaluate the effect of antioxidant supplementation through the consumption of blueberry, cranberry and pomegranate extract capsules (1 of each per day), the effect of the autonomic balance in hypertensive and normotensive adults.
Status | Completed |
Enrollment | 54 |
Est. completion date | December 2016 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 59 Years |
Eligibility |
Inclusion Criteria: - diagnosis of hypertension - group Hypertensives - Healthy people - group Normotensive Exclusion Criteria: - Patients with glycated hemoglobin > 7%, - Patients with a diagnosis of cardiovascular disease, - Patients with LDL-cholesterol> 160 mg/dL (non-diabetics) - Pregnant women, - Cigarret smokers, - Diabetics using more than one drug in addition to metformin, - Patients with LDL-cholesterol> 130 mg/dL (non-diabetic using statin), - LDL cholesterol = 100 mg / dL (patients on statin), - Patients with valvular heart disease, - Pulmonary hypertension, - Patients with collagen disease, - Patients with type of cancer, - Complex arrhythmia, - Those patients with any chronic crippling pathology. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Sao Paulo General Hospital | Fundação de Amparo à Pesquisa do Estado de São Paulo |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Effect of antioxidants on heart rate variability in 29 normotensive subjects and 30 hypertensive patients | Antioxidant supplementation should improve heart rate variability as a consequence of improved antioxidant capacity | 4 weeks | |
Secondary | Effect of antioxidants on insulin resistance in 29 normotensive subjects and 30 hypertensive patients | Supplementation with antioxidants should improve insulin resistance | 4 weeks | |
Secondary | Effect of antioxidants on blood pressure in 29 normotensive subjects and 30 hypertensive patients | Supplementation with antioxidants should improve blood pressure | 4 weeks | |
Secondary | Effect of antioxidants on antioxidant capacity in 29 normotensive subjects and 30 hypertensive patients | Supplementation with antioxidants should improve antioxidant capacity | 4 weeks |
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