Hypertension Clinical Trial
Official title:
Treatment Adherence and Blood Pressure Outcome Among Hypertensive Out-patients in Two Tertiary Hospitals in Sokoto, Northwestern Nigeria
Verified date | March 2018 |
Source | University of Ibadan |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
It is estimated that more than 70% of patients on antihypertensive medications do not take
them as prescribed. Treatment non-adherence practice may be particularly higher in developing
countries where there is poor accessibility to medicines and healthcare services, coupled
with low level of awareness of the lifelong nature of hypertension treatment among patients.
Optimal control of blood pressure has been reported to reduce the incidence of morbidity and
mortality associated with hypertension. Thus, adoption of healthy lifestyle as well as
ensuring regular and continuous adherence to prescribed medications are integral to
successful management of hypertension to achieve the target blood pressure goals.
The present study comprehensively evaluated adherence to pharmacotherapy and
non-pharmacological measures among ambulatory hypertensive patients attending two healthcare
institutions in Sokoto, Northwestern Nigeria. Reasons for treatment non-adherence were
evaluated, while perception and beliefs about hypertension and its management were also
explored, with pharmacist-led patient-specific adherence education provided as appropriate to
resolve the knowledge gap(s). Association between treatment adherence and blood pressure
outcome at contact and the subsequent 2-months clinic appointment were investigated.
Patients aged 18 years and above, with a primary diagnosis of hypertension, and who were on
antihypertensive medications for at least 3-months were recruited from the medical outpatient
clinic of Usmanu Danfodiyo University Teaching Hospital and the Specialist Hospital, both
within Sokoto metropolis, Sokoto state, Northwestern Nigeria. Newly diagnosed patients,
in-patients and those who declined participation were excluded from the study.
Status | Completed |
Enrollment | 605 |
Est. completion date | May 30, 2017 |
Est. primary completion date | May 30, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Patients aged 18 years and above, with a primary diagnosis of hypertension, and who were on antihypertensive medications for at least 3-months were enrolled. Exclusion Criteria: - Newly diagnosed patients, in-patients and those who declined participation were excluded from the study |
Country | Name | City | State |
---|---|---|---|
Nigeria | Usmanu Danfodiyo University Teaching Hospital | Sokoto |
Lead Sponsor | Collaborator |
---|---|
University of Ibadan |
Nigeria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Questionnaire with a nine-item adherence scale to assess the level of adherence to medication | Questionnaire with a nine-item adherence scale was used to assess the level of adherence to medication, while dichotomous Yes/No response option was used to evaluate the level of adherence to the 4-domains of non-pharmacological lifestyle modifications, specifically smoking, alcohol, exercise, and salt-restriction. Using the Statistical Package for Social Sciences version 22 at p < 0.05 level of significance, descriptive statistics including frequency and percentage was used to summarise the data on these parameters | 5 hours on Thursday clinic days, 16 weeks | |
Secondary | Perception and belief about hypertension and treatment | Modified Brief Illness Perception Questionnaire, and 9-item Belief bout Medicine Questionnaire with a 5-point likert scale was used to evaluate the perception and belief of patients about hypertension and the treatment. Descriptive statistics including frequency, percentage and 50th percentile was used to summarise the data on perception and belief about hypertension and treatment, using the Statistical Package for Social Sciences version 22. | 5 hours on Thursday clinic days, 16 weeks | |
Secondary | Data collection form to retrieve the average of two consecutive blood pressure readings (Systolic and Diastolic) | Data collection form was designed to retrieve the average of two consecutive blood pressure readings (Systolic and Diastolic) in individual patient's case note at contact and at the 2-months clinic appointment. Descriptive statistics including frequency, mean ± standard deviation was used to summarise these continuous variable data Chi-square and student's t-test were used to evaluate the relationship between treatment adherence and blood pressure outcome | 4 hours on Thursday clinic days, 16 weeks |
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