Solar Lighting to Reduce Indoor Air Pollution in Rural Uganda

Hypertension Clinical Trial

Official title:

Solar Lighting Intervention Trial to Reduce Indoor Air Pollution and Improve Adult Respiratory Health in Rural Uganda

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03351504
• Other study ID #: 2017P000306/PHS
• Status: Completed
• Phase: N/A
• Start date: February 7, 2018
• Est. completion date: October 31, 2020

Study information

• Verified date: December 2020
• Source: Massachusetts General Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the impact of a solar lighting system on kerosene lamp use, levels of indoor air pollution, and health in women living in rural Uganda. Half of the participants will receive the lighting systems immediately, while the other half will receive them after an 18 month delay.

Description:

One fifth of the global population relies on kerosene lamps for lighting, yet few studies have focused on kerosene lighting as a source of indoor air pollution. In our preliminary studies performed in Uganda, we show that homes using solar lighting have much lower levels of indoor air pollution compared to homes using kerosene lighting. The primary goal of this study is to determine the extent to which solar lighting will reduce kerosene use and indoor air pollution in rural Uganda, whether this intervention improves lung health, and to identify the role bacteria in our gut have on determining whether or not people will get sick from indoor air pollution.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: October 31, 2020
• Est. primary completion date: October 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Women living in Nyakabare Parish, Uganda with no prior history of chronic lung disease

Exclusion Criteria:

• Current active tuberculosis in any family member

Related Conditions & MeSH terms

• Hypertension
• Pollution Related Respiratory Disorder
• Pollution; Exposure
• Respiration Disorders
• Respiratory Tract Diseases

Intervention

Other:
• Solar lighting system
consisting of a solar panel, rechargeable lead acid battery, charge controller, wiring and switches to 4 lighting points fitted with LED bulbs. This system will include a two-year service warranty.

Locations

Country	Name	City	State
Uganda	Mbarara University of Science and Technology	Mbarara
United States	Massachusetts General Hospital	Boston	Massachusetts

Sponsors (3)

Lead Sponsor	Collaborator
Massachusetts General Hospital	Harvard School of Public Health, Mbarara University of Science and Technology

Countries where clinical trial is conducted

United States,  Uganda, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fine particulate matter (PM2.5) and Black Carbon	Sampling for PM2.5 and Black Carbon over 48 hours will be collected	48 hour
Secondary	Daily use of solar lighting system (hours per day)	A current monitory is installed as part of the solar lighting system that measures the hours per day each light switch is turned on	baseline, 3 months, 6 months, 12 months after the intervention
Secondary	Blood pressure	Resting blood pressure	baseline, 3 months, 6 months, 12 months after the intervention
Secondary	Forced Expiratory Volume in one Second (FEV1)	Pre- and Post- bronchodilator spirometry	baseline, 3 months, 6 months, 12 months after the intervention
Secondary	Heart rate variability	Resting 10 minute heart rate variability	baseline, 3 months, 6 months, 12 months after the intervention
Secondary	Stool microbiome	Microbial sequencing of the stool will be performed	baseline, 3 months, 6 months, 12 months after the intervention
Secondary	Qualitative interviews	1:1 qualitative interviews will be performed with participants	Post-intervention