Hypertension Secondary Clinical Trial
Official title:
Huai'an First People's Hospital
Verified date | August 2021 |
Source | Huai'an No.1 People's Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational [Patient Registry] |
Obstructive sleep apnea syndrome (OSAS) causes nocturnal chronic intermittent hypoxia (CIH) that contributes to the development of hypertension. CIH profiles, including the its length, speed and intensity were widely different in individuals. Until recently, the influence of OSAS-related IH profiles on hypertension development has not been fully explored. The present study aimed to investigate the effects of different CIH properties on blood pressure (BP) and short-term blood pressure variability (BPV) in severe OSAS patients. Continuous positive airway pressure (CPAP) prevents the airway collapse, avoids the occurrence of intermittent hypoxemia and arousal, is the preferred treatment for OSAS and has been widely used in clinical. In theory, CPAP maintains upper airway patency and preserves ventilation, thereby inhibits the chain reaction over activation of the sympathetic nervous system and blood pressure regulating mechanism, thus CPAP treatment have adequate scientific basis to cause a substantial reduction arterial blood pressure, but controlled studies showed either no effect or only a minor decrease in arterial blood pressure by 1.4 and 2.5 mmHg respectively.The current, which type of combination of hypertension OSA patients can obtain the best antihypertensive benefit from CPAP therapy is still under debate.
Status | Completed |
Enrollment | 78 |
Est. completion date | December 30, 2021 |
Est. primary completion date | December 30, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: 1. BP=180/110mmHg,but=140/90mmHg 2. without taking oral antihypertensive drugs. Exclusion criteria. (1) patients who had been hospitalized for cardiac or respiratory exacerbation<6wk prior to recruiting; (2) with autonomic nervous system diseases or endocrine disorders which might influence BP; (3) unwilling to participate in the study. |
Country | Name | City | State |
---|---|---|---|
China | Department Of Respiratory Medicine,Huai'an First People's Hospital,Nanjing Medical University | Huai'an | Jiangsu |
Lead Sponsor | Collaborator |
---|---|
Huai'an No.1 People's Hospital | The First Affiliated Hospital with Nanjing Medical University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | awake systolic blood pressure(SBP)changes | as the mean systolic blood pressure measurements during a supine resting period of 1 0minute at awake state | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | sleep systolic blood pressure(SBP)changes | as the average of systolic blood pressure values during sleep | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | sympathetic-parasympathetic nerve balance changes | Studies using spectral analysis of R-R intervals have reported that the power spectrum contains both low-frequency(LF,0.04-0.15 Hz)and high-frequency peaks(HF,0.15-0.5Hz),HF power reflects parasympathetic activity,whereas LF power primarily reflects sympathetic activity with a parasympathetic component.The LF-to-HF ratio(LF/HF)is commonly regarded as an index of sympathovagal balance | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | renin-angiotensin-aldosterone systemchanges | as the levels of plasma angiotension ?( Ang I) and angiotension ?( Ang ?) before and after CPAP treatment | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | AHI changes | the combined number of apnea and hypopnea episodes per hour of sleep | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | TST90 changes | percentage of sleep time with oxygen saturation < 90% | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | oxygen desaturation index(ODI) changes | oxygen desaturation index | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | event-related systolic blood pressure elevation (?SBP) changes | as the gap between the peak value of postapneic SBP and lowest SBP during a obstructive respiratory event | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | systolic blood pressure(SBP)index | as the number of ?SBP>10mmHg per hour of sleep time. | change from Baseline Systolic Blood Pressure at 2 weeks | |
Primary | Desaturation rate | The rate of fall in SpO2 was counted as the change in the percentage of SpO2 per second during apnea | one night |
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