Hypertension Clinical Trial
Official title:
Additive Value of Biological and Electrocardiographic Biomarkers for Risk Stratification in Hypertension
Risk stratification of hypertensive patients includes assessment of traditional
cardiovascular risk factors and subclinical target organ damages particularly left
ventricular hypertrophy (LVH).
LVH may routinely screened by transthoracic echocardiography by measuring the left
ventricular mass (LVM).
However, transthoracic echocardiography suffers from several pitfalls: poor reproducibility,
technical limitations and unavailability at a first evaluation by general practitioners.
Other biomarkers may be particularly helpful in hypertension risk stratification. The
amplitude of the R wave in aVL lead is a simple validated ECG parameters of LVH and a strong
predictor of cardiovascular events and mortality.
Plasma N-terminal pro Brain Natriuretic Peptide (NT-proBNP) is also strongly related to LVM
and is an independent predictor of all-cause mortality in hypertension.
The main objective of our study is to determine the additive prognostic value of R wave in
aVL and NT proBNP on all-cause and cardiovascular mortality.
Secondary objectives are to determine the addition prognostic value of NT-proBNP and R wave
in aVL combined in comparison to each marker taken into account
This study will include 1600 patients who had a work-up of their hypertension in the
Cardiology Department of Croix-Rousse Hospital (Hospices Civils de Lyon, Lyon, France) from
January 1997 to January 2014.
Their data will be collected in an Access database; their vital status will be obtained by
the INSEE unit CépiDC.
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