Hypertension Clinical Trial
Official title:
The Effects of Doxazosin and Nifedipine on Blood Pressure Variability and Uric Acid in Plasma in Hypertensive Patients
Hypertension is one of the most common cardiovascular diseases, which is a major risk factor
for stroke and cardiovascular events. Accumulated data has shown that target-organ damage is
related not only to 24-h mean intra-arterial BP, but also to BP variability (BPV) in
subjects with essential hypertension. There are many studies about the effects of different
kinds of drugs on blood pressure, but the clinical researches about the impacts of
antihypertensive drugs on BPV are limited, and the conclusion is still controversial.
In addition, recent studies found that the occurrence and development of hypertension,
especially essential hypertension, are closely related with hyperuricemia. Serum UA is an
independently prognostic indicator for the development of hypertension. Some studies have
observed the effects of different kinds of antihypertensive drugs on uric acid level in
hypertensive patients. After adjustment, calcium channel blockers are associated with a
lower risk of incident gout among people with hypertension. However, the effects of alpha
blockers on uric acid in plasma are still not very clear.
Therefore, we performed this study to observe the different effects of alpha blocker and
calcium channel blocker on blood pressure variability and uric acid level in hypertensive
patients.
Hypertension is one of the most common cardiovascular diseases, which is a major risk factor
for stroke and cardiovascular events. Traditionally, cardiovascular risk stratification in
hypertensive patients was based on the average blood pressure (BP) measured in the clinic.
Accumulated data has shown that target-organ damage is related not only to 24-h mean
intra-arterial BP, but also to BP variability (BPV) in subjects with essential hypertension.
Growing evidence demonstrated that BPV has considerable prognostic value for all-cause
mortality and cardiovascular outcomes, independent of average BP. At present, the normal
range of BPV is not very clear. There are many studies about the effects of different kinds
of drugs on blood pressure, but the clinical researches about the impacts of
antihypertensive drugs on BPV are limited, and the conclusion is still controversial.
In addition, recent studies found that the occurrence and development of hypertension,
especially essential hypertension, are closely related with hyperuricemia. Accumulated data
has shown that a significant and independent association between the uric acid level and the
onset of hypertension in both men and women participants. Serum UA is an independently
prognostic indicator for the development of hypertension. Some studies have observed the
effects of different kinds of antihypertensive drugs on uric acid level in hypertensive
patients. After adjustment, diuretics, β blockers, angiotensin converting enzyme inhibitors
and non-losartan angiotensin Ⅱ receptor antagonists are associated with an increased risk of
gout. In contrast, calcium channel blockers and losartan are associated with a lower risk of
incident gout among people with hypertension. However, the effects of alpha blockers on uric
acid in plasma are still not very clear.
Therefore, we performed this study to observe the different effects of alpha blocker and
calcium channel blocker on blood pressure variability and uric acid level in hypertensive
patients.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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