Hypertension Clinical Trial
Official title:
The Effects of Nifedipine and Metoprolol on Blood Pressure Variability in Northern Chinese: a Randomized Crossover Study
Hypertension is one of the most common cardiovascular diseases, which is a major risk factor
for stroke and cardiovascular events. Traditionally, cardiovascular risk stratification in
hypertensive patients was based on the average blood pressure (BP) measured in the clinic.
Accumulated data has shown that target-organ damage is related not only to 24-h mean
intra-arterial BP, but also to BP variability (BPV) in subjects with essential hypertension.
Growing evidence demonstrated that BPV has considerable prognostic value for all-cause
mortality and cardiovascular outcomes, independent of average BP.
At present, the normal range of BPV is not very clear. There are many studies about the
effects of different kinds of drugs on blood pressure, but the clinical researches about the
impacts of antihypertensive drugs on BPV are limited, and the conclusion is still
controversial.
Hypertension is one of the most common cardiovascular diseases, which is a major risk factor
for stroke and cardiovascular events. Traditionally, cardiovascular risk stratification in
hypertensive patients was based on the average blood pressure (BP) measured in the clinic.
Accumulated data has shown that target-organ damage is related not only to 24-h mean
intra-arterial BP, but also to BP variability (BPV) in subjects with essential hypertension.
Growing evidence demonstrated that BPV has considerable prognostic value for all-cause
mortality and cardiovascular outcomes, independent of average BP.
The hypertension prevalences in the high latitude and cold regions are much higher than
those in the low latitude and warm regions. In China, the prevalences of hypertension are
gradually increased from the South to the North. Heilongjiang province is the "high-risk"
region for hypertension, with a prevalence of 30.48%. This may be due to the combined
effects of lower average temperature and higher intake of salt and saturated fatty acid,
which Increased sympathetic nerve excitability, and eventually lead to elevation of blood
pressure. Therefore, it is essential to formulate the best treatment of hypertension
according with the physical characteristics of northern Chinese.
At present, the normal range of BPV is not very clear. There are many studies about the
effects of different kinds of drugs on blood pressure, but the clinical researches about the
impacts of antihypertensive drugs on BPV are limited, and the conclusion is still
controversial.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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