Isometric Handgrip Exercise for Blood Pressure Management

Hypertension Clinical Trial

Official title:

Cardiovascular Response to Isometric Resistance Training in People With Hypertension for Blood Pressure Management

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02458443
• Other study ID #: UNewEngland
• Status: Completed
• Phase: N/A
• Start date: February 2016
• Est. completion date: December 2016

Study information

• Verified date: December 2020
• Source: University of New England, Australia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Recent meta-analyses suggest isometric resistance training (IRT) may be superior to aerobic exercise for lowering blood pressure. The investigators intend to conduct the largest, longest, prospective, double-blind randomized controlled trial using isometric resistance training to reduce blood pressure to reduce hypertension.

Description:

We are looking to assess the effect of isometric exercise on ambulatory blood pressure in participants aged 40-70 years who are either pre- or mild hypertensive; either un-medicated or taking medication to control their blood pressure. Our secondary aims are to examine whether the size of blood pressure change is different in those people taking or not taking anti-hypertensive medication, to determine the anti-hypertensive mechanism to IRT, and to establish rate of de-training effects after participants have ceased IRT.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 70 Years

Eligibility

Inclusion Criteria:

• Blood pressure above 120/80 currently not taking anti-hypertensive medications whose doctor has suggested would benefit from exercise; and

• people currently taking beta blockers for blood pressure management.

Exclusion Criteria:

• Younger than 30yrs and older than 70 yrs;

• unable to voluntary participate;

• unable to participate under doctor's recommendation;

• smokers;

• arthritis or carpal tunnel which may be aggravated with handgrip exercise;

• known cardiovascular disease (angina) and the following co-morbid conditions:

• obesity,

• insulin resistance,

• depression,

• mobility impairment,

• sleep apnoea,

• fatty liver disease or

• renal disease

Related Conditions & MeSH terms

• Hypertension

Intervention

Other:
• Isometric resistance training
Isometric handgrip exercise using a hand dynamometer

Locations

Country	Name	City	State
Australia	UNE Exercise Physiology Lab	Armidale	New South Wales

Sponsors (1)

Lead Sponsor	Collaborator
University of New England, Australia

Country where clinical trial is conducted

Australia, 

References & Publications (1)

Carlson DJ, Dieberg G, Hess NC, Millar PJ, Smart NA. Isometric exercise training for blood pressure management: a systematic review and meta-analysis. Mayo Clin Proc. 2014 Mar;89(3):327-34. doi: 10.1016/j.mayocp.2013.10.030. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in systolic and diastolic blood pressure		Change measures: baseline and 12 weeks
Secondary	Compare and contrast change in systolic and diastolic blood pressure of medicated and un-medicated participants		Baseline and 12 weeks
Secondary	Detraining effects, changes in systolic and diastolic blood pressure after cessation of Isometric Resistance Training	End of exercise protocol and 12 weeks after completion	12 weeks and 24 weeks