The Screening and Analysis of Plasma Biomarkers in Irreversible PAH-CHD

Hypertension,Pulmonary Clinical Trial

Official title: The Screening and Analysis of Plasma Biomarkers in Irreversible Pulmonary Arterial Hypertension Associated With Congenital Heart Disease

Status Completed

Clinical Trial Summary

The purpose of this study is to analyse the sensitivity and specificity of circulating endothelial cells to predict irreversible pulmonary arterial hypertension associated with congenital heart disease.

Clinical Trial Description

predict to recruit 100 patients with pulmonary arterial hypertension (PAH)associated with CHD，under the commitment of the children's parents，take 3-4ml central venous blood before the corrective surgery，then calculate the number of the circulating endothelial cells by flow cytometer AND detect the expression of micro RNAs to screen out the biomarker，through the 6 months follow-up, separated the reversible and irreversible PAH,then to carry on the statistics. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Hypertension
• Hypertension, Pulmonary
• Hypertension,Pulmonary

• NCT number: NCT02267200
• Study type: Observational
• Source: Shanghai Jiao Tong University School of Medicine
• Status: Completed
• Phase: N/A
• Start date: October 2014
• Completion date: September 2016