Glu298Asp Polymorphism and Blood Pressure

Hypertension Clinical Trial

Official title:

The Effects of Beetroot Bread on Postprandial Blood Pressure According to Glu298Asp Polymorphism in the eNOS Gene

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02037308
• Other study ID #: 10/18G
• Secondary ID: University of Re
• Status: Completed
• Phase: N/A
• First received: January 13, 2014
• Last updated: January 13, 2014
• Start date: June 2010
• Est. completion date: December 2012

Study information

• Verified date: January 2014
• Source: University of Reading
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Food Standards Agency
• Study type: Interventional

Clinical Trial Summary

The Glu298Asp polymorphism has been linked to increased risk of cardiovascular events, proposed to be due to reduced nitric oxide production by eNOS reported in some but not all studies. We hypothesise that beetroot-enriched bread interacts with the Glu298Asp polymorphism of the eNOS gene to lower blood pressure and increase plasma nitrate/nitrite, particularly in carriers of the T allele, which have been associated with lower eNOS activity and increased risk of hypertension.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: December 2012
• Est. primary completion date: October 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

• Male

• A signed consent form

• Age 18-64 years

• Body mass index - 18.5-30 kg/m2

• Non-smoking, healthy individuals

• Normal blood pressure at screening (< 150/90)

Exclusion Criteria:

• Subjects with anaemia

• Sufferers of chronic illnesses

• Individuals with food allergies

• People with diabetes

• People with coeliac disease

• Women

• Vegetarians

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Hypertension

Intervention

Dietary Supplement:
• Bread

Locations

Country	Name	City	State
United Kingdom	Food and Nutritional Sciences, University of Reading	Reading	Berkshire

Sponsors (1)

Lead Sponsor	Collaborator
University of Reading

Country where clinical trial is conducted

United Kingdom, 

References & Publications (2)

Hobbs DA, Goulding MG, Nguyen A, Malaver T, Walker CF, George TW, Methven L, Lovegrove JA. Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. J Nutr. 2013 Sep;143(9):1399-405. doi: 10.3945/jn.113.175778. Epub 2013 Jul 24. — View Citation

Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA. Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr. 2012 Dec 14;108(11):2066-74. doi: 10.1017/S0007114512000190. Epub 2012 Mar 14. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postprandial blood pressure		30 minute intervals for a period of 6 hours	No
Secondary	Postprandial plasma NOx		30 minute intervals for a total period of 6 hours	No