Hypertension Clinical Trial
Official title:
Observational Study to Investigate the Effectiveness of Eprosartan on Pulse Pressure in Hypertensive Patients With Metabolic Syndrome
The study is to identify the effectiveness of Eprosartan on pulse pressure in hypertensive
patients with metabolic syndrome
-Definition of pulse pressure (PP): Difference between systolic and diastolic blood pressure
produced one heart beat.
Primary Objective
-To assess the changes of pulse pressure at 12 weeks
Secondary Objectives
- To assess the changes of pulse pressure at 4, 24 weeks
- To assess the changes of systolic blood pressure and diastolic blood pressure at each
visit
- Percentage of responder rate* at each visit and time to get normalized BP from
enrollment
- Responder rate at last visit
- To assess IIEF-5 (5-item Version of the International Index of Erectile Function) score
at enrollment and 24 weeks (percentage of patients with ED according to IIEF-5, Changes
of IIEF-5 domains)
- Percentage of patients with erectile dysfunction (ED) according to IIEF-5 and changes
of PP in subgroup (age 65, body mass index (BMI) 23, diabetes mellitus, dyslipidemia,
benign prostate hypertrophy)
- Analysis of correlation between ED and concomitant disease and concomitant medications
in patients who received Eprosartan
- Score changes of Framingham 10-year Coronary Heart Disease (CHD) risk at 1st visit, 4th
visit
- Percentages of Eprosartan monotherapy and multiple antihypertensive therapies at
enrollment and last visit
- Reason for treatment discontinuation (Inadequate BP control, adverse events, others)
- Adverse events
- Responder rate: SBP <140mmHg and DBP <90mmHg (SBP <140mmHg and DBP <85mmHg for
patients with diabetes mellitus)
;
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