Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme

Hypertension Clinical Trial

Official title:

Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01963507
• Other study ID #: ACE RT
• Status: Completed
• Phase: N/A
• First received: October 9, 2013
• Last updated: October 11, 2013
• Start date: April 2010
• Est. completion date: April 2013

Study information

• Verified date: October 2013
• Source: Federal University of São Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The study aimed to evaluate the chronic effects of resistance training on blood pressure and biochemical exams in hypertensive elderlies and the influence of the polymorphism of the angiotensin converting enzyme in these response.

Description:

To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 136
• Est. completion date: April 2013
• Est. primary completion date: April 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 60 Years to 85 Years

Eligibility

Inclusion Criteria:

• Hypertensives

• Age 60 to 85 years

• Nonactive

Exclusion Criteria:

• Orthopedic problems or other problem that prevented the exercises

• Change in drug treatment during protocol

• Absence in more than 25% of the exercise sessions

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Hypertension

Intervention

Behavioral:
• Resistance training
Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR).

Locations

Country	Name	City	State
Brazil	UNIMED	Santos	SP

Sponsors (2)

Lead Sponsor	Collaborator
Federal University of São Paulo	Fundação de Amparo à Pesquisa do Estado de São Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood Pressure	Blood pressure was measured by Ambulatorial Monitoring Blood Pressure before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	HDL-cholesterol	HDL-cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	Total Cholesterol	Total cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	Glycemia	Glycemia was analyzed by colorimetric assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	Triacylglycerol	Triacylglycerol was analyzed by colorimetric assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	PAI-1	PAI-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	ICAM-1	ICAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	VCAM-1	VCAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	Adiponectin	Adiponectin was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	TNF alpha	TNF alpha was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	C Reactive Protein	C Reactive Protein was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	Angiotensin II	Angiotensin II was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	Angiotensin Converting Enzyme	Angiotensin Converting Enzyme was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes
Secondary	Angiotensin 1-7	Angiotensin 1-7 was analyzed by ELISA assay, before and after 16 weeks of intervention.	16 weeks	Yes