Hypertension Clinical Trial
Official title:
Does Ultraviolet Irradiation Reduce Platelet Reactivity and Improve Coronary Microvascular Function in Man?
Endothelium derived nitric oxide (NO) regulates vascular tone and blood pressure in man. NO
also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory
and repair mechanisms. NO may also be a mediator in the release of the endogenous
fibrinolytic factor, tissue-plasminogen activating factor (t-PA) from the endothelium.1 Via
these actions it plays a very important role in protection of the vasculature from
atherothrombosis and clinical sequelae such as myocardial infarction and stroke.
Visible and ultraviolet (UV) light relax vascular smooth muscles by producing NO in a
phenomenon known as photorelaxation.2 The investigators have demonstrated significant stores
of pre-formed, bound NO and other nitrosospecies in human skin, which are rapidly released
upon exposure to UVA.3 The investigators have demonstrated recently that serum nitrite and
nitroso-species are increased after standing in a UVA phototherapy cabinet and that local
UVA exposure is associated with increased forearm arterial blood flow that is independent of
skin temperature. The investigators have also demonstrated a fall in mean arterial blood
pressure in subjects exposed UVA.
Cardiovascular morbidity and the prevalence of hypertension vary with latitude. The
investigators hypothesise that some of this geographical variation may be explained by a
diminished sunlight/UVA exposure with attendant negative effects upon NO bio-availability.4
To further examine the potential beneficial effects of UVA exposure we will examine the
effects of whole-body UVA upon platelet activation and upon myocardial/coronary arterial
flow reserve. The investigators will correlate these measures with systemic nitrate, nitrite
and nitroso-species content in healthy volunteers.
HYPOTHESES
1. UVA irradiation enhances coronary flow reserve in healthy volunteers.
2. UVA irradiation suppresses platelet activation in healthy volunteers.
3. UVA irradiation enhances the release of endogenous fibrinolytic factors in healthy
volunteers.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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