Beetroot Enriched Bread, Blood Pressure and Vascular Function

Hypertension Clinical Trial

Official title:

The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01706718
• Other study ID #: 10/18
• Secondary ID: University of Re
• Status: Completed
• Phase: N/A
• First received: September 27, 2012
• Last updated: October 12, 2012
• Start date: June 2010
• Est. completion date: October 2010

Study information

• Verified date: October 2012
• Source: University of Reading
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dietary nitrate is known to lower blood pressure. Beetroot is a rich source of nitrate and could therefore be an important dietary component in the management of hypertension and cardiovascular disease, however consumption is relatively low. We evaluated the effects of beetroot enriched bread ingestion on acute microvascular reactivity, arterial stiffness and blood pressure response in healthy men.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: October 2010
• Est. primary completion date: October 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

• Male

• A signed consent form

• Age 18-64 years

• Body mass index - 18.5-30 kg/m2

• Non-smoking, healthy individuals

• Normal blood pressure at screening (< 150/90)

Exclusion Criteria:

• Subjects with anaemia

• Sufferers of chronic illnesses

• Individuals with food allergies

• People with diabetes

• People with coeliac disease

• Women

• Vegetarians

Related Conditions & MeSH terms

• Hypertension

Intervention

Dietary Supplement:
• Bread

Locations

Country	Name	City	State
United Kingdom	University of Reading	Reading	Berkshire

Sponsors (1)

Lead Sponsor	Collaborator
University of Reading

Country where clinical trial is conducted

United Kingdom, 

References & Publications (1)

Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA. Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr. 2012 Dec 14;108(11):2066-74. doi: 10.1017/S0007114512000190. Epub 2012 Mar 14. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Vascular reactivity	Forearm blood flow by Laser Doppler Imaging with iontophoresis	Change from baseline at 2, 4 and 6 hours after bread consumption
Secondary	Arterial stiffness	Pulse wave analysis (PWA) and velocity (PWV)	Change from baseline at 2, 4 and 6 hours after bread consumption
Secondary	Blood pressure	By ambulatory blood pressure monitor	Change from baseline at 30 minute intervals for 7 hours
Secondary	Plasma nitrate		Every 30 minutes for 7 hours
Secondary	Plasma nitrite		Every 30 minutes for 7 hours