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NCT01670903 Clinical Trial

The Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients

Hypertension Clinical Trial

Official title:
the Effect of Angiotensin II Type 1 Receptor Antagonists on the Size and Expansion Rate of Abdominal Aortas in Hypertensive Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01670903
Other study ID # SHEBA-12-8336-DS-CTIL
Secondary ID
Status Recruiting
Phase N/A
First received August 19, 2012
Last updated August 19, 2012
Start date May 2011

Study information
Verified date August 2012
Source Sheba Medical Center
Contact Daniel Silverberg, MD
Phone 035302712
Email Daniel.Silverberg@sheba.health.gov.il
Is FDA regulated No
Health authority Israel: Ministry of Health
Study type Observational

Clinical Trial Summary

Abdominal aortic aneurysm (AAA) is a common disease that develops from degeneration of the aortic wall. The natural history of AAA is gradual expansion and if left untreated may result in rupture and death. The mechanism of the development of this disease is unknown however it appears to be multifactorial and possibly related to degradation processes within the arterial wall. There is growing evidence that Angiotensin receptor blockers ( ARBS) may have an inhibitory effect on remodelling processes within the arterial wall, thus inhibiting degeneration of the vessel wall.

Study hypothesis: ARBS are associated with smaller diameters of aortas among hypertensive patients, and are associated with a lower rate of aortic expansion compared to other antihypertensive drugs.

Recruitment information / eligibility
Status Recruiting
Enrollment 150
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 50 Years to 80 Years
Eligibility Inclusion Criteria:

- medically treated hypertensive patients, ages 50-80

Exclusion Criteria:

- pregnant women

- patients previously treated for aortic disease

- unable to sign informed consent, minors

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Sheba Medical Center Tel Hashomer
Israel Sheba Medical Center Tel Hashomer

Sponsors (1)
Lead Sponsor Collaborator
Sheba Medical Center

Country where clinical trial is conducted

Israel, 

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