Renal Denervation in Patients With Uncontrolled Hypertension in Chinese

Status Not yet recruiting

Clinical Trial Summary

The purpose of this study is to determine whether renal denervation is safe and effective in the treatment of Chinese patients with uncontrolled hypertension.

Clinical Trial Description

Prevalence of hypertension is increasing in China.While actually,the controlled rate of hypertension is relatively low,though numerous safe and effective pharmacological therapies are used in clinical practice.Studies confirmed that renal sympathetic nerves contributed to development and perpetuation of hypertension. Previous study has stated that renal denervation was effective and safe in patients with resistant hypertension, while little data is known in Chinese patients. We hypothesis that renal denervation is effective and safe in treatment of Chinese patients with uncontrolled hypertension. This trial plan to recruit 100 patients(Ablation group VS Control group = 1:1) with a follow up duration of 3 years.Patients in ablation group will receive percutaneous renal denervation combined with necessary antihypertension drugs and patients in control group will receive appropriate antihypertension drugs. We aim to explore the long term safety and validity of renal denervation in Chinese patients with uncontrolled hypertension. ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Hypertension

Clinical Trial Details

NCT number	NCT01390831
Study type	Interventional
Source	The Second People's Hospital of Chengdu
Contact	Jian Xiong Liu, MD
Phone	862886621522-5205
Email	steven.ljx@163.com
Status	Not yet recruiting
Phase	Phase 1/Phase 2
Start date	November 2011
Completion date	June 2015

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