Hypertension Clinical Trial
Official title:
Electrical Baroreflex Stimulation - Sympathetic Activity
Electrical stimulation of carotid baroreceptors (baropacing) acutely decreases arterial
pressure in patients with refractory hypertension. The reduction in blood pressure seems to
be mediated through sympathetic inhibition with concomitant reduction in the activity of the
renin-angiotensin system. Indeed, switching on and off the stimulation is accompanied by
decreases and increases in central sympathetic vasoconstrictor outflow, respectively. Plasma
renin concentration also decreases with acute electrical baroreflex stimulation.
In some patients chronic baropacing is associated with long-term blood pressure reduction.
However, there is sparse information as to the relative contribution of blood pressure
regulating systems to account for the acute and chronic effects of baropacing. Sympathetic,
renal, and vascular mechanisms are of special interest. Furthermore, technical aspects of
electrical baroreflex stimulation may play a role, e.g. worsening of the electrical contact
between the stimulating electrodes and the baroreceptor afferents.
This study is designed to answer the following primary questions:
1. Does chronic electrical stimulation of carotid baroreceptors inhibit sympathetic
vasoconstrictor tone also in the long-term?
2. Does sympathetic vasoconstrictor tone increase on switching off chronic baropacing?
Such an increase would confirm electrical integrity of the system and proper contact to
the baroreceptor afferents.
3. Does acute electrical baroreflex stimulation decrease renal vascular resistance?
4. Does acute electrical baroreflex stimulation influence glucose delivery to skeletal
muscle and change insulin sensitivity? The study follows an open-label observational
design and it is planned to recruit up to 30 patients over 3 years.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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