Endothelial Function in Patients With Pulmonary Arterial Hypertension

Status Completed

Clinical Trial Summary

Clinical Trial Description

The objectives of the current study are to identify and evaluate new prognostic non-invasive and serological markers in patients with pulmonary hypertension. The focus will be on L-arginine metabolism and to clarify its influence on endothelial function. The investigators also want to evaluate differences in plasma concentrations of L-arginine/NO metabolites and non-invasively assessed endothelial function based on specific PH-therapy. Furthermore, the investigators aim to transfer the results gained from the investigators study population to in-vitro systems in order to carefully characterize the involved signal transduction pathways. Thereby the investigators hope to identify potentially new therapeutic targets in PH or patient subgroups preferably benefitting from established therapeutic options. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01317134
Study type	Interventional
Source	Universitätsklinikum Hamburg-Eppendorf
Contact
Status	Completed
Phase	N/A
Start date	October 2010
Completion date	July 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04076241` - Effects of Adding Yoga Respiratory Training to Osteopathic Manipulative Treatment in Pulmonary Arterial Hypertension	N/A
Completed	`NCT05521113` - Home-based Pulmonary Rehabilitation With Remote Monitoring in Pulmonary Arterial Hypertension
Recruiting	`NCT04972656` - Treatment With Ambrisentan in Patients With Borderline Pulmonary Arterial Hypertension	N/A
Completed	`NCT04908397` - Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension	Phase 1
Active, not recruiting	`NCT03288025` - Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)	N/A
Completed	`NCT01959815` - Novel Screening Strategies for Scleroderma PAH
Recruiting	`NCT04266197` - Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 2B Study	Phase 2
Active, not recruiting	`NCT06092424` - High Altitude (HA) Residents With Pulmonary Vascular Diseseases (PVD), Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) vs Sea Level (LA)	N/A
Enrolling by invitation	`NCT03683186` - A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension	Phase 3
Terminated	`NCT02060487` - Effects of Oral Sildenafil on Mortality in Adults With PAH	Phase 4
Terminated	`NCT02253394` - The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study	Phase 4
Withdrawn	`NCT02958358` - FDG Uptake and Lung Blood Flow in PAH Before and After Treatment With Ambrisentan	N/A
Terminated	`NCT01953965` - Look at Way the Heart Functions in People With Pulmonary Hypertension (PH) Who Have Near Normal Right Ventricle (RV) Function and People With Pulmonary Hypertension Who Have Impaired RV Function. Using Imaging Studies PET Scan and Cardiac MRI.	Phase 2
Not yet recruiting	`NCT01649739` - Vardenafil as add-on Therapy for Patients With Pulmonary Hypertension Treated With Inhaled Iloprost	Phase 4
Withdrawn	`NCT01723371` - Beta Blockers for Treatment of Pulmonary Arterial Hypertension in Children	Phase 1/Phase 2
Unknown status	`NCT01712997` - Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension Patients	Phase 3
Completed	`NCT01548950` - Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension	N/A
Completed	`NCT01165047` - Nitric Oxide, GeNO Nitrosyl Delivery System	Phase 2
Completed	`NCT00963027` - Effect of Esomeprazole on the Pharmacokinetics of Oral Treprostinil	Phase 1
Completed	`NCT00942708` - Safety and Efficacy of Fluoxetine in Pulmonary Arterial Hypertension	Phase 2