Hypertension Clinical Trial
Official title:
Effects of Eplerenone on Blood Pressure, Heart and Kidney in Elderly Hypertensive Early Stage Chronic Kidney Disease Patients
The purpose of this study is to determine whether eplerenone is effective in the treatment of blood pressure, heart function, renal function in elderly hypertensive stage1 (eGFR>=90ml/min/1.73m2) and stage2 (eGFR 60-89ml/min/1.73m2) chronic kidney disease (CKD) patients.
Chronic kidney disease (CKD) was reported to be affecting 11% of the all population. This
number is much higher in the elderly population and may be as high as 30%. CKD is an
independent risk factor of cardiovascular disease (CVD). This is called "Cardio-renal
Continuum". The renin-angiotensin-aldosterone system (RAS) plays pivotal roles in both
cardiovascular and renal functions.
The increased oxidative stress by activated RAS on vascular endothelium is one of important
factor to development of Cardio-renal Continuum. The blockade of RAS by angiotensin I
converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers (ARBs) has been
reported to ameliorate the renal disease and CVD; however,they do not completely suppress
RAS and may induce aldosterone breakthrough that plays important roles for the development
of CVD. Eplerenone, a selective aldosterone blocker, is effective against essential
hypertension; however, little is known about the effects of eplerenone on heart and kidney
functions in elderly hypertensive CKD patients. In this study, we assessed the efficacy of
eplerenone on heart and kidney functions in elderly hypertensive early stage (stage1
(eGFR>=90ml/min/1.73m2) and stage2 (eGFR 60-89ml/min/1.73m2)) CKD patients.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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