Hypertension Clinical Trial
Official title:
ACCESS STUDY (Angiotensin Receptor Blocker Combined With Calcium Antagonist Evaluation of Safety and Lowering of Systolic Blood Pressure Study) ARB/CCB Combination Therapy: Efficacy vs an ACE-inhibitor/CCB Combination and Use as First Line Therapy.
This study is looking to evaluate which drug combination, olmesartan/amlodipine or
perindopril/amlodipine, is better at lowering blood pressure in people with mild to moderate
hypertension. The investigators will be enrolling people who are either currently taking
medication to lower their blood pressure or who have been recently diagnosed with high blood
pressure and are not yet on medication.
Patients on medication for their blood pressure will be asked to stop taking this medication
for 2 to 4 weeks. If their blood pressure is suitable (not too high or low) they will be
randomised to one of their treatment arm:
Group 1 will receive Perindopril on its own (5mg for 4 weeks followed by 10mg for 8 weeks).
There will be 80 patients in this group.
Group 2 will receive Perindopril and Amlodipine together (5mg/5mg for 4 weeks, 10mg/5mg for
a further 4 weeks then 10mg/10mg for the final 4 weeks). There will be 80 patient in this
group.
Group 3 will receive Olmesartan and Amlodipine together (20mg/5mg for 4 weeks, 40mg/5mg for
a further 4 weeks then 40mg/10mg for the final 4 weeks). There will be 120 patients in this
group.
During the study we will measure the patients blood pressure and heart rate, weight and
perform routine blood tests. They will also have ECGs (3 occasions) and 24 hour blood
pressure monitor (4 occasions).
At the end of the study patients pre-study medication will be restarted or they will be put
on to a suitable alternative.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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