The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression

Hypertension Clinical Trial

Official title:

The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression in Mildly Hypertensive Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00948363
• Other study ID #: 1335
• Status: Completed
• Phase: N/A
• First received: July 27, 2009
• Last updated: June 28, 2017
• Start date: August 2009
• Est. completion date: December 2010

Study information

• Verified date: June 2017
• Source: Oslo University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.

Description:

An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 118
• Est. completion date: December 2010
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 35 Years to 69 Years

Eligibility

Inclusion Criteria:

• Systolic blood pressure 130-159 mmHg

• Diastolic blood pressure 85-99 mmHg

• Body mass index <35 kg/m2

Exclusion Criteria:

• Systolic blood pressure >160 mmHg or <129 mmHg

• Diastolic blood pressure >100 mmHg or <84 mmHg

• Current use or need for blood pressure lowering medication

• Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.

Related Conditions & MeSH terms

• Hypertension

Intervention

Other:
• Kiwi fruits
Daily intake of 3 kiwi fruits for 8 weeks
• Apple
Daily intake of 1 apple (equivalent in energy) for 8 weeks

Locations

Country	Name	City	State
Norway	Department of Preventive Cardiology	Oslo
Norway	Oslo University Hospital	Oslo

Sponsors (2)

Lead Sponsor	Collaborator
Oslo University Hospital	University of Oslo

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood pressure		8 weeks
Secondary	Endothelial function		8 weeks