Antihypertensive Effect of Simvastatin in Hypertensive Patients

Status Recruiting

Clinical Trial Summary

Few trials have investigated the hypotensive effect of the Statins. Most were not specifically aimed at this pleiotropic effect or had methodological problems. The possible hypotensive effect may explain part of the favorable results of the Statins use on cardiovascular prevention independently from its action on the cholesterol profile.

The purpose of this study is to determine the effect of Simvastatin on the blood pressure

Clinical Trial Description

This is a randomized double blind parallel clinical trial where hypertensive patients with controlled or uncontrolled blood pressure and without evidence of target-organ damage will be selected. Subjects will receive Simvastatin 40 mg once daily or placebo and a baseline and eight weeks ABPM will performed. The main outcome will be the difference in systolic BP in the 24h-ABPM. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Hypertension

Clinical Trial Details

NCT number	NCT00704548
Study type	Interventional
Source	Hospital de Clinicas de Porto Alegre
Contact	Miguel Gus, MD
Phone	+55512101-8420
Email	mgus@terra.com.br
Status	Recruiting
Phase	Phase 4
Start date	June 2008
Completion date	September 2009

View Details

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