Hypertension Clinical Trial
Official title:
Blood Pressure and Metabolic Effects of Nebivolol Compared With Hydrochlorothiazide and Placebo in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose
This study is being done to see if the blood pressure and metabolic effects of an approved drug nebivolol is comparable to that of another approved drug hydrochlorothiazide (HCTZ) and placebo in hypertensive patients.
This study is double blind (neither you nor the physician will know when you are receiving
placebo, which is an inactive compound such as a sugar pill, or active study drugs nebivolol
or hydrochlorothiazide).
All participants will also receive lisinopril, an angiotensin converting enzyme, or losartan,
an angiotensin receptor blocker. All medications are approved and marketed for the treatment
of hypertension.This study is being conducted in about 500 patients at approximately 80
research centers in the United States.
The study consists of approximately 9 study visits over a period of 5 months. During these
visits, patients will undergo routine health exams and some special laboratory tests such as
an oral glucose tolerance test.
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