Hypertension Clinical Trial
Official title:
A Comparative Study of the Efficacy of Irbesartan/Hydrochlorothiazide 300/25 mg Versus Valsartan/Hydrochlorothiazide 160/25 mg Using Home Blood Pressure Monitoring in the Treatment of Mild to Moderate Hypertension
The primary objective is to compare the efficacy of irbesartan/hydrochlorothiazide 300/25mg
against valsartan/hydrochlorothiazide 160/25mg in reducing mean systolic blood pressure
(SBP) as measured by home blood pressure monitoring (HBPM) after 24 weeks compared with
baseline.
The secondary objectives are:
- To compare the percentage of patients with normal blood pressure as measured by HBPM
and at the doctor's office at weeks 16 and 24
- To compare the differences in mean Diastolic Blood Pressure (DBP), mean morning and
evening SBP and DBP evaluated by HBPM at weeks 16 and 24
- To compare the difference in mean SBP evaluated by HBPM at week 16
- To compare the differences in mean SBP and DBP evaluated at the doctor's office at
weeks 16 and 24
- To determine the incidence and severity of adverse events
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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