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NCT00448162 Clinical Trial

The Chinese Mutation Hotspot of ENaC Causing Liddle's Syndrome and the Association of ENaC Variations and Hypertension

Hypertension Clinical Trial

Clinical Trial Details — Status: Suspended

Administrative data
NCT number NCT00448162
Other study ID # SGL-032-01
Secondary ID
Status Suspended
Phase N/A
First received March 15, 2007
Last updated March 30, 2011
Start date May 2005
Est. completion date December 2009

Study information
Verified date May 2009
Source Peking Union Medical College
Contact n/a
Is FDA regulated No
Health authority China: Ministry of Health
Study type Observational

Clinical Trial Summary

The variations of ENaC have an impact on the degradation of epithelial sodium channels and sodium reabsorption, and thus are associated with hypertension and hypokalemia.

Liddle's syndrome is a rare monogenic form of autosomal-dominant hypertension caused by truncating or missense mutations in the C-termini of epithelial sodium channel β- or γ-subunit encoded by SCNN1B or SCNN1G. Our purpose is to determine the hotspot of mutation causing Chinese Liddle's syndrome.

The second purpose is to determine wether the polymorphisms of ENaC are associated with hypertension in Chinese. Some polymorphisms of ENaC associated with hypertension may be genetic risk factors for Chinese hypertension.

Recruitment information / eligibility
Status Suspended
Enrollment 2000
Est. completion date December 2009
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 8 Years to 70 Years
Eligibility Inclusion Criteria:

- Clinical diagnosis of hypertension and Liddle's syndrome

- Clinical diagnosis of normal controls with no cardiovascular disease

Exclusion Criteria:

- Hypertension caused by other single gene mutation

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
China FuWai Hospital Beijing Beijing

Sponsors (1)
Lead Sponsor Collaborator
Peking Union Medical College

Country where clinical trial is conducted

China, 

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